Two series of new benzoxazepines substituted with different alkyl amino ethyl chains were synthesized comprising synthetic steps of inter and intamolecular Mitsunobu reaction, lithium aluminium hydride (LAH) reduction, ...

We have reported a microwave-assisted ligand-free Pd-catalyzed domino C-C/C-N coupling reaction to construct diverse isoindolinone derivatives using amides and isocyanides as coupling partner. This strategy provides ...

The antimalarial activity of a series of 4-anilinoquinolines was modeled with topological and other functional descriptors using feature selection approaches combinatorial protocol in multiple linear regression (CP-MLR) ...

Phytochemical investigation of seed coats of Pterospermum acerifolium afforded two new phytoceramides (1, 2) and two new acylated phytosterol glucosides (3, 4) together with five known compounds (5-9). Their structures ...

An efficient micelle promoted one-pot synthesis of 3-amino alkylated indoles have been developed via three-component Mannich-type reaction from secondary amines, aldehydes and indoles in water under mild reaction conditions. ...

In continuation of our drug discovery program on Indian medicinal plants, the gastro protective mechanism of chebulinic acid isolated from Terminalia chebula fruit was investigated. Chebulinic acid was evaluated against ...

An efficient ultrasound promoted synthesis of 2, 3-disubstituted benzo[b]furans in the ionic liquid, [bmim]BF4 at room temperature is reported. 5-exo-dig carbanion-yne intramolecular cyclization is mediated using anhydrous ...

An unprecedented synthesis of aromatic ring annulated pyridines from suitably substituted primary allylamines via intramolecular electrophilic aromatic cyclization mediated by molecular iodine under mild conditions is described.

Licochalcone A (I) isolated from the roots of Chinese licorice, is the most promising antimalarial compound reported so far. In continuation of our drug discovery program, we isolated two similar chalcones, medicagenin ...

An operationally simple and efficient cascade strategy to access substituted isoindolo[2,1-a]quinoxalines via one step copper-catalysed C-N coupling of substituted 2H-isoindole-1-carbaldehyde and substituted 2-halophenylamines ...