http://dkr.cdri.res.in:8080/xmlui/handle/123456789/8 2026-04-19T13:40:16Z http://dkr.cdri.res.in:8080/xmlui/handle/1/1719 Krc sheikh, Arshi Tuberculosis, 1,2,3-Triazoles, antimycobacterial activity, molecular docking Tuberculosis, 1,2,3-Triazoles, antimycobacterial activity, molecular docking 2016-01-01T00:00:00Z http://dkr.cdri.res.in:8080/xmlui/handle/123456789/1702 Synthesis of Enantiomerically Enriched Indolines and Tetrahydroisoquinolines from (S)-Amino Acid-Derived Chiral Carbocations: An Easy Access to (3S,4R)-Demethoxy-3-isopropyl Diclofensine Manna, S K; Panda, Gautam Enantiomerically enriched indolines and tetrahydroisoquinolines were synthesized within 5 min to 2 h in high yields from easily accessible (S)-amino acids derived chiral carbocations. The diastereoselective Friedel-Crafts reaction is promoted by Lewis acid (AlCl3) offering trans-diastereoselectivity. The rate of the reaction and diastereoselectivity of the product are significantly influenced by steric hindrance of substituents of amino acids and aryl groups. The methodology can be applied for the synthesis of enantiomercally enriched bioactive scaffold (3S, 4R)-demethoxy-3-isopropyl diclofensine. 2014-01-01T00:00:00Z http://dkr.cdri.res.in:8080/xmlui/handle/123456789/1700 Asymmetric Assembly of Steroidal Tetracyclic Skeletons Gupta, Preeti; Panda, Gautam Steroids have long played a vital role in the organic synthesis because of their unique structural design and associated biological properties. In recent years, asymmetric synthesis has emerged as a powerful tool for assembling the tetracyclic framework with high level of molecular diversity. This review summarizes the latest developments in the enantioselective syntheses of both natural and synthetic steroids incorporationg the carbocyclic skeleton. The approaches to the synthesis of steroids and related molecules are based primarily on the use of chiral starting materials, the employment of reagent-controlled asymmetric induction assisted by chiral complexes, chiral Lewis acids or organocatalysts, or the utilisation of chiral auxiliaries. 2014-01-01T00:00:00Z http://dkr.cdri.res.in:8080/xmlui/handle/123456789/1697 Substituent controlled reactivity switch: selective synthesis of alpha-diazoalkylphosphonates or vinylphosphonates via nucleophilic substitution of alkyl bromides with Bestmann-Ohira reagent Pramanik, M M D; Chaturvedi, A K; Rastogi, Namrata We report a substituent controlled nucleophilic displacement of alkyl bromides with Bestmann-Ohira reagent yielding either dimethyl diazoalkylphosphonates or (E)-vinylphosphonates. The dimethyl diazoalkylphosphonates could be readily converted into corresponding (E)-vinylphosphonates in the presence of Cu following nitrogen elimination in quantitative yields. 2014-01-01T00:00:00Z