Synthesis and biological evaluation of 2,3,4-triarylbenzopyran derivatives as SERM and therapeutic agent for breast cancer†

Kumar, Shailesh; Deshpande, Shreekant; Kitchlu, Shakti; Chandra, Vishal; Dwivedi, Anila; Nayak, V L; Konwar, Rituraj; Prabhakar, Y S; Sahu, D P

dc.contributor.author	Kumar, Shailesh
dc.contributor.author	Deshpande, Shreekant
dc.contributor.author	Kitchlu, Shakti
dc.contributor.author	Chandra, Vishal
dc.contributor.author	Dwivedi, Anila
dc.contributor.author	Nayak, V L
dc.contributor.author	Konwar, Rituraj
dc.contributor.author	Prabhakar, Y S
dc.contributor.author	Sahu, D P
dc.date.accessioned	2012-04-18T11:55:25Z
dc.date.available	2012-04-18T11:55:25Z
dc.date.issued	2009
dc.identifier.citation	Bioorganic & Medicinal Chemistry 2009, 17(19), 6832–6840	en
dc.identifier.uri	http://hdl.handle.net/123456789/758
dc.description.abstract	A novel class of 2,3,4-triarylbenzopyrans has been synthesized and were evaluated for their selective estrogen receptor rmodulation and anti-proliferative activities. 10a and 11c exhibited 73.91 and 69.24 % inhibition as estrogen antagonistic activity respectively. 11a showed lowest MIC at 6.971µM against MCF-7 cell line and 10h showed lowest MIC at 6.971µM against MDA-MB-231 cell line	en
dc.format.extent	995030 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication No.7778	en
dc.subject	SERMs	en
dc.subject	Estradiol	en
dc.subject	2,3,4-triarylbenzopyrans	en
dc.title	Synthesis and biological evaluation of 2,3,4-triarylbenzopyran derivatives as SERM and therapeutic agent for breast cancer†	en
dc.type	Article	en