LC-MS/MS METHOD FOR SIMULTANEOUS ANALYSIS OF CLADRIN AND EQUOL IN RAT PLASMA AND ITS APPLICATION IN PHARMACOKINETICS STUDY OF CLADRIN

Lakshmi, Manickavasagam; Gupta, Sonal; Mishra, Smriti; Rakesh, Maurya; Naibedya, Chattopadhyay; Jain, G K

dc.contributor.author	Lakshmi, Manickavasagam
dc.contributor.author	Gupta, Sonal
dc.contributor.author	Mishra, Smriti
dc.contributor.author	Rakesh, Maurya
dc.contributor.author	Naibedya, Chattopadhyay
dc.contributor.author	Jain, G K
dc.date.accessioned	2011-09-30T11:46:05Z
dc.date.available	2011-09-30T11:46:05Z
dc.date.issued	2010
dc.identifier.citation	Medicinal Chemistry Research, 19.1), S79-S79	en
dc.identifier.uri	http://hdl.handle.net/123456789/729
dc.description.abstract	A rapid and selective LC-MS/MS method for simultaneous analysis of cladrin and equol in female rat plasma has been developed and validated. The chromatographic separation was carried out on RP18 column and MS/MS analysis was performed in triple quadrupole mass spectrometer with electrospray ionization (ESI). The method was linear for the concentration range from 7.8ng/ml to 1000ng/ml for cladrin and 3.9ng/ml to 1000ng/ml for equol. The intra-day and inter-day accuracy and precision of the method were within the acceptable limits. The validated LC-MS/MS method was successfully applied for the pharmacokinetics study of cladrin at 10mg/kg in female S.D. rats.	en
dc.format.extent	84425 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI COMMUNICATION NO. 7956	en
dc.subject	Cladrin	en
dc.subject	Equol	en
dc.subject	rat plasma	en
dc.subject	LC-MS/MS	en
dc.title	LC-MS/MS METHOD FOR SIMULTANEOUS ANALYSIS OF CLADRIN AND EQUOL IN RAT PLASMA AND ITS APPLICATION IN PHARMACOKINETICS STUDY OF CLADRIN	en
dc.type	Article	en