5-Styryl-4, 5-cis-1, 3-oxazole-2-one-4-carboxylic acid (CDRI-85/92) is a new proton pump inhibitor presently in advanced stage of preclinical trials as antiulcer pharmacophore. Since proton pump inhibitors are prodrugs ...

[1:-Isoleucine,5-isoleucine]-angiotensin II and [3-proline,5-isoleucine]-angiotensin II were synthesized by the solid-phase method using dicyclohexylcarbodiimide as the condensing agent. The formation of the arginyl-proline ...

Sodium and liquid ammonia reduction of hayatinin ethyl ether affords a non-phenolic component, identified as dl-4'-O-methyl-7-0-ethyl-N-methylcoclaurine, and a phenolic component identified as dl-N-methylcoclaurine. The ...

1-Isoleucine,5-isoleucine]-angiotensin II and [3-proline,5-isoleucine]-angiotensin II were synthesized by the solid-phase method using dicyclohexylcarbodiimide as the condensing agent. The formation of the arginyl-proline ...

The synthesis of some 2-& 4-pyridylethyl ureas & thioureas described involves pyridylethylation of ammonia and the condensation of the resulting pyridylethyl amine with isocyanate or isothiocyanate respectively.

A series of 2-substituted and 2,3-disubstituted benzo(6,7)quinazoline-4-ones have been synthesized as possible CNS depressants. 2-Substituted products, viz. hydrazino, phenylhydrazino and amino, have been obtained by the ...

The synthesis and pharmacological evaluation of certain 5-substituted amino-6,7,S,9-tetrahydro- 5H- benzocycloheptenes, 1-(6,7 ,S,9-tetrahydro-5H -benzocycloheptenyl) hydrazines, 5- (r -diethylamino) propyl-6, 7,S,9- ...

I-P-D-Ribofuranosyl-5-ethoxycarbonyl-4-hydroxy- 1,2-dihydropyrid-2-one has been synthesized starting from 2,4-dihydroxy-5-. The monomercury derivative of the starting compound on condensation with 2,3,5-tri-O-chloride ...