Genetic differentiation of populations residing in areas of high malaria endemicity in India

Sinha, Swapnil; Arya, Vandana; Agarwal, Sarita; Habib, Saman

dc.contributor.author	Sinha, Swapnil
dc.contributor.author	Arya, Vandana
dc.contributor.author	Agarwal, Sarita
dc.contributor.author	Habib, Saman
dc.date.accessioned	2010-09-09T08:53:15Z
dc.date.available	2010-09-09T08:53:15Z
dc.date.issued	2009
dc.identifier.citation	Journal of Genetics, 88(1), 2009, 77-80	en
dc.identifier.uri	http://hdl.handle.net/123456789/592
dc.description.abstract	The frequency of five single nucleotide polymorphisms (SNPs) (TNF: rs1800630, rs362525, ICAM-1: rs5491, TLR9:: rs187084 and FCGR2A: rs1801274), previously correlated with severity of falciparum malaria in some world populations, was used to analyze genetic differentiation among 55 ethnically diverse populations of India. Significant differentiation of the north Indian Tharu tribe inhabiting the malaria-endemic Terai region and tribal populations of the falciparum-endemic eastern region of India was revealed. In addition to high frequency of the protective FCGR2A exon 4 A allele and low frequency of the TLR9 C susceptibility allele in these populations, near-fixation of the α-thalassemia – α3.7 allele was observed in Indian Tharus and was indicative of their genetic proximity to Tharus of western or central Nepal.	en
dc.format.extent	95493 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.subject	thalassemia	en
dc.subject	falciparum	en
dc.subject	erythrocytic	en
dc.subject	malaria	en
dc.title	Genetic differentiation of populations residing in areas of high malaria endemicity in India	en
dc.type	Article	en