MicroRNAs belong to the family of ncRNAs and had gained importance due to its role in complex biochemical pathways. Changes in the expression of protein coding genes are the major cause of leukemia. Role of miRNAs as tumor ...

The lack of cure to age associated Parkinson’s disease (PD) has been challenging the efforts of researchers as well as health care providers. Recent evidences suggest that diabetic patients tend to show a higher future ...

Enzymes play a very vital role in maintaining the homeostasis inside the body. Improper functioning of enzymes is associated with many diseases. Insulin-degrading enzyme (IDE), a ubiquitously expressed zinc metalloprotease, ...

The increase in chemical diversity has increased the need to adjudicate the toxicity of different chemical compounds raising the burden on the demand of animal testing. The toxicity evaluation requires, time consuming and ...

The present study was performed to investigate the involvement of mitochondrion – specific endonuclease G in piracetam (P) induced protective mechanisms. Studies have showed the antiapoptotic effect of piracetam but still ...

Okadaic acid (OKA) is potent inhibitor of protein phosphatases 1/2A (PP2A). Inhibition of PP2A leads to hyperphosphorylation of Tau protein. Hyperphosphorylated Tau protein is present in intraneuronal neurofibrillary tangles ...

FasL mediated preferential apoptosis of bystander CTLs while protection of infected CD4+T cells remains one of the hallmarks of immune evasion during HIV infection. The property of infected host cells to evade cell-autonomous ...

Background: Caenorhabditis elegans has emerged as a very powerful model for studying the host pathogen interactions.Despite the absence of a naturally occurring viral infection for C. elegans, the model is now being exploited ...

The vertical transmission of HIV-1 from the mother to fetus is known, but the molecular mechanism regulating this transmission is not fully characterized. The fetus is highly protected by the placenta, which does not permit ...

Chloramphenicol (CAP) is a potent and efficient antibiotic used since years against many pathogens. Despite being highly effective, it shows severe toxicity in the form of Aplastic anemia (AA) and bone marrow suppression. ...