Causal prophylactic activity of a new 8-aminoquinoline derivative against plasmodium cynomolgi B in rhesus monkeys

dc.contributor.author	Puri, S K
dc.contributor.author	Dutta, G P
dc.date.accessioned	2009-09-08T08:39:03Z
dc.date.available	2009-09-08T08:39:03Z
dc.date.issued	1990
dc.identifier.citation	Indian J Med Research (1990) 91,197-199	en
dc.identifier.uri	http://hdl.handle.net/123456789/503
dc.description.abstract	A new 8-aminoquinoline derivative, N'-(3-acetyl-4-5-dihydro-2 furanyl)-N4-(6-methoxy-8-quinolinyl)1,4-pentanediamine, synthesized at CDRI, Lucknow, showed causal prophylactic activity at 3.16mg/kg x3 doses (on day -1,0 and+1)against sporozoite induced P.cynomelgi B infection in rhesus monkeys. Single dose of IOmg/kg of this compound on day 0 also prevented establishment of patent infection. Activity of the compound was comparable to that of primaquine (with causal prophylactic activity at 1.78mg/kg in three day test and at 10.0mg/kg in single dose test).	en
dc.format.extent	1826945 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.title	Causal prophylactic activity of a new 8-aminoquinoline derivative against plasmodium cynomolgi B in rhesus monkeys	en
dc.type	Article	en