Abstract:
A new 8-aminoquinoline derivative, N'-(3-acetyl-4-5-dihydro-2 furanyl)-N4-(6-methoxy-8-quinolinyl)1,4-pentanediamine, synthesized at CDRI, Lucknow, showed causal prophylactic activity at 3.16mg/kg x3 doses (on day -1,0 and+1)against sporozoite induced P.cynomelgi B infection in rhesus monkeys. Single dose of IOmg/kg of this compound on day 0 also prevented establishment of patent infection. Activity of the compound was comparable to that of primaquine (with causal prophylactic activity at 1.78mg/kg in three day test and at 10.0mg/kg in single dose test).
