Cell growth inhibitory action of an unusual labdane diterpene, 13-epi-sclareol in breast and uterine cancers in vitro

Sashidhara, K V; Rosaiaha, J N; Kumar, Abdhesh; Bid, H K; Konwar, Rituraj; Chattopadhyay, Naibedya

dc.contributor.author	Sashidhara, K V
dc.contributor.author	Rosaiaha, J N
dc.contributor.author	Kumar, Abdhesh
dc.contributor.author	Bid, H K
dc.contributor.author	Konwar, Rituraj
dc.contributor.author	Chattopadhyay, Naibedya
dc.date.accessioned	2009-09-07T09:27:48Z
dc.date.available	2009-09-07T09:27:48Z
dc.date.issued	2007
dc.identifier.citation	Phytother Res.( 2007),21(11),1105-8	en
dc.identifier.uri	http://hdl.handle.net/123456789/502
dc.description.abstract	In the course of our studies on the isolation of bioactive compounds from the roots of Coleus forskohlii, a traditional herb in India, rare 13-epi-sclareol has been isolated, and its structure determined by extensive 2D NMR. And also this is the first report of isolation from this plant. Isolated compound showed anti-proliferative activity in breast and uterine cancers in vitro. The anti-proliferative activity of 13-epi-sclareol is comparable with Tamoxifen in terms of IC50 and also showed concentration dependent increased apoptotic changes in breast cancer cell line, MCF-7.	en
dc.format.extent	89806 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communicatin No. 7122	en
dc.subject	13-epi-sclareol	en
dc.subject	Diterpene	en
dc.subject	Anti-cancer	en
dc.subject	Coleus forskohlii	en
dc.subject	Apoptosis	en
dc.title	Cell growth inhibitory action of an unusual labdane diterpene, 13-epi-sclareol in breast and uterine cancers in vitro	en
dc.type	Article	en