Pharmacokinetics & Metabolism: Recent submissions

Now showing items 1-20 of 40

LC-MS/MS assay for quantification of a novel Antitubercular molecule S006-830: Pharmacokinetic and plasma protein binding studies in Rats

Hidau, Mahendra Kumar; Singh, Yeshwant; Shahi, Sudhir; Mounika, Poojari; Singh, Shio Kumar (2015)

A highly sensitive and selective LC-MS/MS assay was developed and validated for determination of a novel antitubercular compound S006-830 in rat plasma. The analyte and internal standard (IS) were extracted from plasma by ...
Pharmacokinetics, tissue distribution and plasma protein binding studies of rohitukine: an potent anti-hyperlipidmic agent

Chhonke, Yashpal S.; Chandasana, Hardik; Kumar, Ashok; Kumar, Deepak; Laxman, Tulsankar Sachin; Mishra, Sunil Kr; Balaramnavar, Vishal M.; Srivastava, Shishir; Saxena, Anil K; Bhatta, Rabi S. (2015)

Rohitukine (RH) is a chromone alkaloid considered as one of the major active components of Dysoxylum binectariferum, exhibiting diverse pharmacological activities such as anti-hyperlipidmic, anti-cancer, anti-inflammatory, ...
A rapid and sensitive LC-MS/MS analysis of diapocynin in rat plasma to investigate in-vitro and in-vivo pharmacokinetics

Chandasana, Hardik; Yashpal; Chhonke, S; Bala, Veenu; Prasad, Yarra Durga; Sharma, Vishnu L.; Bhatta, Rabi S. (2014)

Natural products have been used traditionally for the treatment and prevention of diseases. Diapocynin is the analogue of the naturally occurring apocynin, a well-known constituent of the Picrorhiza kurroa. It has antioxidant ...
Insights into the Pharmacokinetic Properties of Antitubercular Drugs

Shukla, Mahendra; Sharma, Abhisheak; Jaiswal, Swati; Lal, Jawahar (2016)

Introduction: The furiously advancing cases of multidrug-resistant tuberculosis (TB) along with the recent emergence of total drug resistant TB and TB-AIDS comorbidity prompt an increasingly solemn threat to global public ...
Multiple-dose pharmacokinetics of a novel, synthetic trioxane-antimalarial compound 97/78 in rats using LC-MS/MS method

Singh, R P; Sabarinath, S; Kushwaha, H N; Gautam, Nagsen; Gupta, R C; Singh, S K (2014)

Multiple dose pharmacokinetic study was studied in rats following oral dose administration at 47 mg/kg. The pharmacokinetic profile of 97/78 was investigated in form of its completely converted in-vivo active metabolite ...
Plasma pharmacokinetics, bioavailability and tissue distribution of agnuside following peroral and intravenous administration in mice using liquid chromatography tandem mass spectrometry

Ramakrishna, Rachumallu; Bhateria, Manisha; Singh, Rajbir; Puttrevu, S K; Bhatta, R S (2016)

Agnuside (AGN), an iridoid glycoside, is the chemotaxonomic marker of the genus Vitex which has gained enormous attention by virtue of its potential health benefits. Regardless of claiming many therapeutic applications ...
Pharmacokinetic Study and Bioavailability of a Novel Synthetic Trioxane Antimalarial Compound 97/63 in Rats

Kushwaha, H N; Mohan, N K; Sharma, A K; Singh, S K (2014)

Single dose pharmacokinetics study of 97/63 (IND191710,2004)-a trioxane antimalarial developed by Central Drug Research Institute, Lucknow, India was studied in rats following intravenous and oral administration. Serum ...
A rapid and sensitive LC-MS/MS analysis of diapocynin in rat plasma to investigate in-vitro and in-vivo pharmacokinetics

Chandasana, Hardik; Chhonker, Y S; Bala, Veenu; Prasad, Y D; Sharma, V L; Bhatta, R S (2014)

Natural products have been used traditionally for the treatment and prevention of diseases. Diapocynin is the analogue of the naturally occurring apocynin, a well-known constituent of the Picrorhiza kurroa. It has antioxidant ...
Pharmacokinetics, dose proportionality and permeability of S002-333 and its enantiomers, a potent antithrombotic agent, in rabbits

Saxena, Amrita; Valicherlaa, G R; Joshi, Pankaj; Saxena, Rohit; Cheruvu, S H; Bhunia, S S; Jain, G K; Siddiqui, H H; Saxena, A K; Gayen, J R (2015)

1. S002-333 [(2-(4'-methoxy-benzenesulfonyl)-2,3,4,9-tetrahydro-1H-pyrido (3,4-b) indole-3-carboxylic acid amide)] is a novel and potent antithrombotic active agent. The present work investigates the pharmacokinetics, ...
Sensitive and high-throughput bioanalysis of fluoxetine and nor-fluoxetine in rabbit and human plasma using SPE-LC-MS/MS

Prasad, Y D; Chhonker, Y S; Chandasana, Hardik; Laxman, T S; Bala, Veenu; Kanojiya, Sanjeev; Ghatak, Sandeep; Bhatta, R S (2015)

Fluoxetine is a commonly prescribed antidepressant agent in psychotherapy. A rapid, selective and sensitive LC-MS/MS method was developed and validated for simultaneous estimation of fluoxetine and its metabolite ...
Do Blood Sampling Sites Affect Pharmacokinetics?

Rangaraj, Nagarjun; Vaghasiya, Kalpesh; Jaiswal, Swati; Sharma, Abhisheak; Shukla, Mahendra; Lal, Jawahar (2014)

Preclinical and clinical pharmacokinetic (PK) profiling is the bottleneck of the drug development process. PK involves assessment of plasma/serum/blood drug concentration at different time points post drug administration. ...
Time Course of the Changes in Novel Trioxane Antimalarial 99/411 Pharmacokinetics upon Antiepileptic Drugs co-administration in SD Rats

Singh, Yeshwant; Kushwaha, H N; Misra, Anamika; Hidau, M K; Singh, S K (2014)

Objective: The study aimed to evaluate the influences of co-administration of antiepileptic drugs (AEDs) on an anti-malarial candidate 99/411 pharmacokinetic (PK) profile. Method: For this, single oral dose PK drug ...
Amphotericin-B entrapped lecithin/chitosan nanoparticles for prolonged ocular application

Chhonker, Y S; Prasad, Y D; Chandasana, Hardik; Vishvkarma, Akhilesh; Mitra, Kalyan; Shukla, P K; Bhatta, R S (2015)

Fungal keratitis is the major cause of vision loss worldwide. Amphotericin-B is considered as the drug of choice for fungal infections. However, its use in ophthalmic drug delivery is limited by the low precorneal residence ...
In-vitro evaluation of Bacopa monniera extract and individual constituents on human recombinant Monoamine oxidase enzymes

Singh, Rajbir; Ramakrishna, Rachumallu; Bhateria, Manisha; Bhatta, R S (2014)

Bacopa monniera (BM) is a traditional Ayurvedic medicinal plant that has been used worldwide for its nootropic action. Chemically standardized extract of BM is now available as over the counter herbal remedy to enhance ...
Quantitative Determination of Microbicidal Spermicide ‘Nonoxynol-9’ in Rabbit Plasma and Vaginal Fluid using LC-ESI-MS/MS: Application to Pharmacokinetic study

Chhonker, Y S; Chandasana, Hardik; Bala, Veenu; Kumar, Lokesh; Sharma, V L; Gupta, Gopal; Bhatta, R S (2014)

Nonoxynol-9 (N-9), a microbicidal spermicide, has been in use as an over-the-counter contraceptive since the 1960s. A detailed account of its pharmacokinetic profile using highly sensitive detection method has not been ...
Erythrocytes based synthetic delivery systems: transition from conventional to novel engineering strategies

Bhateria, Manisha; Rachumallu, Ramakrishna; Singh, Rajbir; Bhatta, R S (2014)

Introduction: Erythrocytes (RBCs) and artificial/synthetic delivery systems such as liposomes, nanoparticles (NPs) are the most investigated carrier systems. Herein, progress made from conventional approach of using RBC ...
Disposition of Pharmacologically Active Dietary Isoflavones in Biological Systems

Wahajuddin; Taneja, Isha; Arora, Sumit; Raju, K S R; Siddiqui, Nida (2013)

Dietary isoflavones, popularly known as phytoestrogens, represent one of the most biologically active classes of flavonoids. Numerous in vitroandin vivostudies provide convincing evidence regarding their beneficial effects ...
Development and validation of a Liquid Chromatography–mass Spectrometry Method for Determination of Amphotericin B in Rabbit Tears and its Application to Ocular Pharmacokinetic Study

Bhatta, R S; Rathi, Chetan; Chandasana, Hardik; Kumar, Devendra; Chhonker, Y S; Jain, G K (2011)

A rapid and sensitive LC-MS-MS method was developed for the quantiﬁcation of amphotericin B in rabbit tears using natamycin as internal standard. The analyte and internal standard were extracted from the tear sample using ...
Simultaneous estimation of E- and Z- isomers of guggulsterone in rabbit plasma using liquid chromatography tandem mass spectrometry and its application to pharmacokinetic study

Bhatta, R S; Chhonker, Y S; Jain, G K (2011)

A sensitive and selective liquid chromatography / tandem mass spectrometric method was developed for simultaneous determination of E- and Z-guggulsterone isomers (antihyperlipidemic drug) in rabbit plasma. Both the isomers ...
Dried Blood Spots in Bioanalysis of Antimalarials: Relevance and Challenges in Quantitative Assessment of Antimalarial Drugs

Taneja, Isha; Erukala, Madhuri; Raju, K S R; Singh, S P; Wahajuddin (2013)

Malaria is the leading parasitic disease in the emerging countries. Therapeutic drug monitoring of antimalarial drugs is becoming increasingly important due to their spreading resistance. Measuring systemic antimalarial ...

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