Synthesis and antitubercular screening of imidazole derivatives

Pandey, Jyoti; Tiwari, Vinod K; Verma, Shyam S; Chaturvedi, Vinita; Bhatnagar, Shalini; Sinha, Sudhir; Gaikwad, A N; Tripathi, R P

dc.contributor.author	Pandey, Jyoti
dc.contributor.author	Tiwari, Vinod K
dc.contributor.author	Verma, Shyam S
dc.contributor.author	Chaturvedi, Vinita
dc.contributor.author	Bhatnagar, Shalini
dc.contributor.author	Sinha, Sudhir
dc.contributor.author	Gaikwad, A N
dc.contributor.author	Tripathi, R P
dc.date.accessioned	2009-08-31T11:33:41Z
dc.date.available	2009-08-31T11:33:41Z
dc.date.issued	2009
dc.identifier.citation	European Journal of Medicinal Chemistry(2009),44, 3350–3355	en
dc.identifier.uri	http://hdl.handle.net/123456789/488
dc.description.abstract	A series of imidazole based compounds were synthesized by reacting simple imidazoles either with alkyl halides in presence of tetrabutylammonium bromide (TBAB) or by conjugate addition of imidazoles to ethyl acrylate or glycosyl olefinic ester. The synthesized compounds were screened against M. tuberculosis where compound 17 exhibited good in vitro antitubercular activity that may serve as a lead for further optimization.	en
dc.format.extent	160798 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication No. 7398	en
dc.subject	Tuberculosis	en
dc.subject	Imidazoles	en
dc.subject	Glycosyl amino ester	en
dc.subject	C-allylation	en
dc.title	Synthesis and antitubercular screening of imidazole derivatives	en
dc.type	Article	en