Synthesis of Galactopyranosyl Amino Alcohols as a new class of Antitubercular and Antifungal Agents

Tewari, Neetu; Tiwari, V K; Tripathi, R P; Chaturvedi, Vinita; Srivastava, A; Srivastava, R; Shukla, P K; Chaturvedi, A K; Gaikwad, A; Sinha, S; Srivastava, B S

Synthesis of Galactopyranosyl Amino Alcohols as a new class of Antitubercular and Antifungal Agents

Tewari, Neetu; Tiwari, V K; Tripathi, R P; Chaturvedi, Vinita; Srivastava, A; Srivastava, R; Shukla, P K; Chaturvedi, A K; Gaikwad, A; Sinha, S; Srivastava, B S

URI: http://hdl.handle.net/123456789/312

Date: 2004

Abstract:

The galactopyranosyl amino alcohols (3-16) were synthesized by regioselective oxirane ring opening of compound 2 with variety of amines and screened for antitubercular and antifungal activities. One of the compounds (16) showed potent activity against M. tuberculosis H37 Rv in vitro and also displayed activity in MDR TB. The compound (16) was found to be superior to ethambutol clinically used anti TB drug in in vitro screen.

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