Asymmetric Distribution of Phosphatidylethanolamine in C. albicans: Possible Mediation by CDRI, a Multidrug Transporter Belonging to ATP Binding Cassette (ABC) Superfamily

Dogra, S; Krishnamurthy, S; Gupta, V; Dixit, B L; Gupta, C M; Sanglard, D; Prasad, R

dc.contributor.author	Dogra, S
dc.contributor.author	Krishnamurthy, S
dc.contributor.author	Gupta, V
dc.contributor.author	Dixit, B L
dc.contributor.author	Gupta, C M
dc.contributor.author	Sanglard, D
dc.contributor.author	Prasad, R
dc.date.accessioned	2008-12-22T13:56:08Z
dc.date.available	2008-12-22T13:56:08Z
dc.date.issued	1999
dc.identifier.citation	Yeast 15,111-121 (1999)	en
dc.identifier.uri	http://hdl.handle.net/123456789/242
dc.description.abstract	By using two molecular probes, we demonstrate that only 4% of total phosphatidylethanolamine (PtdEtn) in the plasma membrane (PM) of a human pathogenic yeast, Candida albicans, is present in its external half. Evidence is presented to show that the availability of PtdEtn could be related to the expression of a multidrug transporter CDRI of C. albicans, and the process is energy-dependent. A homozygous CDRI disruptant strain of C. albicans shows almost 23% reduction in the external labelling of PtdEtn. This report shows that, similar to human MDRs, yeast multidrug transporter could also be involved in aminophospholipid translocation.	en
dc.format.extent	4238905 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.subject	membrane asymmetry	en
dc.subject	multidrug resistance	en
dc.subject	aminophospholipid translocation	en
dc.subject	ABC transporter	en
dc.subject	C. albicans	en
dc.title	Asymmetric Distribution of Phosphatidylethanolamine in C. albicans: Possible Mediation by CDRI, a Multidrug Transporter Belonging to ATP Binding Cassette (ABC) Superfamily	en
dc.type	Article	en