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Tuftsin-Bearing Liposomes as Antibiotic Carriers in Treatment of Macrophage Infections

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dc.contributor.author Gupta, C M
dc.contributor.author Haq, W
dc.date.accessioned 2008-11-25T03:15:39Z
dc.date.available 2008-11-25T03:15:39Z
dc.date.issued 2005
dc.identifier.citation Methods Enzymol.391,291-304 (2005) en
dc.identifier.uri http://hdl.handle.net/123456789/240
dc.description.abstract Tuftsin is a tetrapeptide (Thr-Lys-Pro-Arg)that specifically binds monocytes, macrophages, and polymorphonuclear leukocytes and potentiates their natural killer activity against tumors and pathogens. The antimicrobial activity of this peptide is significantly increased by attaching at the C-terminus a fatty acyl residue through the ethylenediamine spacer arm. This activity is further augmented by incorporating the modified tuftsin in the liposomes. The tuftsin-bearing liposomes not only enhance the host's resistance against a variety of infections but also serve as useful vehicles for the site-specific delivery of drugs in a variety of macrophage-based infections, such as tuberculosis and leishmaniasis. en
dc.format.extent 4899192 bytes
dc.format.mimetype application/pdf
dc.language.iso en en
dc.title Tuftsin-Bearing Liposomes as Antibiotic Carriers in Treatment of Macrophage Infections en
dc.type Article en


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