Significant association of metabolic indices, lipid profile, and androgens levels with prostate cancer

Abstract

Aim: To compare the levels of metabolic indices, lipid profile, androgens, and prostate specific antigen between prostate cancer and BPH and between the grades of prostate cancer in a cross-sectional study. Materials and methods: We investigated the levels of metabolic indices, lipid profile, androgens, and prostate specific antigen in a cross-sectional study to compare their levels between prostate cancer and BPH and across the grades of prostate cancer. The study enrolled 95 cases of prostate cancer and 95 that of benign prostatic hyperplasia (BPH). Prostate gland volume was measured using transrectal ultrasound. Further, prostate cancer patients were classified into low grade and high grade. Unpaired t-test for normally distributed variables and Man-Whitney U test for non-normal variables were used to compare the differences between low and high grades. Results: We found that prostate cancer patients had significantly higher levels of insulin, testosterone, PSA, cholesterol, triglycerides, low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) in comparison to the BPH patients. Higher levels of these parameters also correlated with a higher grade of the disease. Conclusions: We conclude that higher levels of insulin, testosterone, PSA, and cholesterol correlate with a higher risk of prostate cancer, and also with a higher grade of the disease.