4-Aminoquinoline-Schiff base Hybrid: Rational Drug Design Approach for Overcoming Chloroquine Resistance in Malaria

Sharma, Rashmi; Pandey, A K; Srivastava, Kumkum; Puri, S K; Singh, S V; Saxena, J K; Chauhan, P M S

dc.contributor.author	Sharma, Rashmi
dc.contributor.author	Pandey, A K
dc.contributor.author	Srivastava, Kumkum
dc.contributor.author	Puri, S K
dc.contributor.author	Singh, S V
dc.contributor.author	Saxena, J K
dc.contributor.author	Chauhan, P M S
dc.date.accessioned	2015-05-27T11:09:30Z
dc.date.available	2015-05-27T11:09:30Z
dc.date.issued	2014
dc.identifier.citation	Chemistry & Biology Interface, 2014, 4(5), 268-280	en
dc.identifier.uri	http://hdl.handle.net/123456789/1533
dc.description.abstract	Antimalarials based on the 4-aminoquinoline-schiff base hybrid coupled with oxalamide functionality as linker are designed and synthesized. The molecules were evaluated for their antiplasmodial activity against choroquine-resistant (CQ-R) K1 and choroquine-sensitive (CQ-S) 3D7 of Plasmodium falciparum strains. Some of the novel compounds were found to be more potent than Chloroquine in vitro against CQ-R strain. Furthermore several molecules also showed promising β-hematin inhibitory activity.	en
dc.format.extent	226984 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CSIR-CDRI Communication No. 8838	en
dc.subject	Antimalarial	en
dc.subject	4-Aminoquinoline	en
dc.subject	Drug resistance	en
dc.subject	Oxalamide	en
dc.subject	Schiff base	en
dc.title	4-Aminoquinoline-Schiff base Hybrid: Rational Drug Design Approach for Overcoming Chloroquine Resistance in Malaria	en
dc.type	Article	en