M235T Polymorphism in the AGT Gene and A/GI8-83 Substitution in the REN Gene Correlate with End Stage Renal Disease

Abstract

Background/Aims This study aimed at investigating if M235T polymorphism in the AGT gene and A/GI8-83 polymorphism in the REN gene correlate with the end stage renal disease (ESRD). Methods We analyzed one hundred and seventy three patients having ESRD and three hundred and twenty-nine individuals with normal kidney function for differences in the genotype distribution of AGT-M235T and REN-A/GI8-83 polymorphisms between the two groups. The data for cases and controls were compared using chi square test. Results We found significantly higher levels of serum creatinine and CRP in cases in comparison to controls (P< 0.0001). Data comparison showed significant association of AGT M235T substitution with ESRD in dominant model (p = 0.008) and in comparison of heterozygous substitution against homozygous common genotype (p = 0.005). Similarly, REN A/GI8-83 polymorphism showed a significant difference in the distribution of genotypes between cases and controls (p= < 0.038) such that heterozygous substitution was significantly more common in the ESRD cases in comparison to homozygous common genotype (p = 0.023). Conclusion We conclude that heterozygous substitutions at AGT M235T and REN A/GI8-83 loci correlate significantly with ESRD in a north Indian population.