Functional Drug Targeting to Erythrocytes In Vivo using Antibody Bearing Liposome as Drug Vehicles

Abstract

Covalent attachment of anti-erythrocyte F(ab')2 to the liposome surface has recently been shown to considerably enhance tne liposome binding to erythrocytes in vivo. These antibody bearing liposomes have nPW been found quite effect1ve-as-vehicles for delivering the antimalarial drug., chloroquine. to erythrocytes in Plasmodium berghei-infected mice. This demonstrates the usefulness of antibody targeted liposomes as carriers for site-specific drug de1ivery.