Theses : Recent submissions

Now showing items 21-40 of 177

Role of tumor microenvironment in maintaining cancer stem cell properties

Cahturvedi, Priyanka; Datta, Dipak (Guide) (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 2020)

Cancer is a multi-stage complex disease involving a cumulative series of gene-environmental interactions leading to dysfunction in multiple mechanisms including machinery for DNA repair, apoptotic and immune responses. ...
Study the Effect of Antispermatogenic Agent- Chebulinic Acid on Male Reproductive System and Benign Prostate Hyperplasia (BPH)

Agarwal, Ankit Kumar; Sachdev, Monika (Guide) (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 208)

Population growth is a major problem worldwide for which several control methods are currently being used that may lead to reduced total fertility rate in men and women. Overpopulation is a significant contributor to ...
Design and Synthesis of Novel Nitrogen Heterocyclic prototypes and their Antiparasitic and Antimicrobial activity

Chauhan, Kuldeep; Chauhan, P.M.S. (Guide) (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 2013)

The field of infectious diseases is ever changing with emerging pathogens, globalization, growing antimicrobial resistance, expanding therapeutic options and continuous development of vaccines and strategies for drug ...
Quest for Target and Diversity Oriented Synthesis of Medicinally Important Natural Product and Natural Product-like Molecules from Amino Acids

Bera, Saurav; Panda, Gautam (Guide) (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 2014)

A major part of the drugs present in the market is natural products or natural productderived. The two main synthetic devices towards the drug development are Targetoriented synthesis (TOS) and Diversity-oriented synthesis ...
Characterization of Nucleosomal Histone Protein(s) of L. donovani for its potential as a vaccine target against Visceral Leishmaniasis

Dube, Anuradha (Guide); Baharia, Rajendra Kumar (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 2013)

Leishmaniasis (cutaneous, mucocutaneous, and visceral) is caused by an intracellular protozoan parasite complex by the invasion of the reticuloendothelial system (spleen, liver and bone marrow). Leishmaniasis is a zoonotic ...
Synthesis of possible Antimalarial Agents and Annulated Heterocyclic Frameworks

Biswas, Subhasish; Batra, Sanjay (Guide) (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 2014)

Malaria is the most fatal of the parasitic diseases responsible for more than a million deaths annually across the globe. Malaria imposes severe socioeconomic burden which has delayed the development in several of the ...
Synthesis of Heterocyclic Scaffolds and Natural Product Mimics Using Morita-Baylis-Hillman Chemistry

Bhowmik, Subhendu; Batra, Sanjay (Guide) (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 2014)

The complexity and structural diversity of natural products have fascinated organic chemists for a very long time. The development of new types of chemical reactions over the past few decades has enabled synthetic chemists ...
Design, Synthesis and Conformational Studies of Peptidomimetics Containing β-Prolines and Application of Titanium(3) Induced Radical Cyclization of Epoxyolefins in Natural Product Synthesis

Basu, Sandip; Chakraborty, Tushar Kanti (Guide) (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 2013)

The thesis entitled “Design, Synthesis and Conformational Studies of Peptidomimetics Containing β-Prolines and Application of Titanium(3) Induced Radical Cyclization of Epoxyolefins in Natural Product Synthesis” consists ...
Design, Synthesis and Conformational Studies of Peptidomimetics Containing β-Prolines and Application of Titanium(3) Induced Radical Cyclization of Epoxyolefins in Natural Product Synthesis

Basu, Sandip; Chakraborty, Tushar Kanti (Guide) (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 2013)

The thesis entitled “Design, Synthesis and Conformational Studies of Peptidomimetics Containing β-Prolines and Application of Titanium(3) Induced Radical Cyclization of Epoxyolefins in Natural Product Synthesis” consists ...
Synthesis and bio-evaluation of hybrid molecules based on aromatics, heterocycles & sugars

Anand, Namrata; Tripathi, R. P (Guide) (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 2013)

The discovery of efficacious new human therapeutic agents is one of humanity’s most crucial responsibilities. Medicinal chemistry is a multidisciplinary science including synthetic organic chemistry, natural products ...
Synthesis of Carbohydrate Derived Scaffolds and Glycosylated Quinoline Derivatives as Potential Bioactive Agents

Azad, Chandra Sourabh; Saxena, A.K. (Guide) (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 2013)

Drug discovery and development is a multidisciplinary process. Among different steps in the process, the first step is the lead generation which involves the design and synthesis of the bioactive molecules. The synthetic ...
Synthetic Studies on ER Active Ligands as Potential Estrogen Agonists/Antagonists

Ansari, Mohammad Imran; Hajela, K. (Guide) (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 2013)
Studies on New Antimalarial Agents: Synthesis and Bioevaluation

Mishra, Mridul; Tripathi, R P (Guide) (2011)

The currently used drugs against various diseases are now gradually losing their potency due to the resistance phenomenon. So the development of new drugs or new biologically active chemical entities is very important ...
Molecular Characterization of Mycobacterium tuberculosis H37Rv Protein(s) involved in Persistence/Latency

Kaur, Satinder; Srivastava, Ranjana (Guide) (2010)

Tuberculosis is the world‘s longest running catastrophe killing more than two hundred people every hour and more than five thousand everyday. According to WHO, someone is infected every second (Dye et al., 1999). Mycobacterium ...
Novel Therapeutic Strategies for the Management of Prostatic Hyperplasia and Molecular Mechanisms involved in these Therapies

Kumar, Rajeev; Gupta, Gopal (Guide) (2010)

In aging men, decline in testicular function coincides with an increase in aromatization of adrenal androgens to estrogens in peripheral adipose tissues, resulting in a significant increase in estrogen to androgen ratio. ...
Study of Toxicity and differential Gene Expression in Mice Following Exposure to selected antimalarial Drugs

Mishra, S.K.; Rath, S. K. (Guide) (2015-10-30)

Ever since the discovery of very first chemotherapeutic drug, questions were raised regarding its not so popular and almost ubiquitous side effects. There always exists a delicate balance between efficacy, tolerability ...
Rational Design of a drug delivery system for intervention in episodic endocrine phenomena in Hypothalamo-Pituitary-Testicular axis

Malik, Ritu; Misra, Amit (Guide) (2015-10-30)
Study on the role of Peroxisome Proliferator Activated Receptor Gamma (PPAR-γ) in gastric ulcer healing

Lahiri, Shawon; Tuhinadri, Sen (Guide); Palit, Gautam (Guide) (2009)

Gastric ulcer is the most prevalent gastro-intestinal disorder and also a major health problem, with a high rate of global incidence occurring across all ages, races and ethnicity. With pluricausal etiologies which are ...
Characterization of RD1 related secretory protein(s) from Mycobacterium tuberculosis H37Rv

Mahmood, Anjum; Arora, Ashish (Guide) (2015-10-30)

Tuberculosis (TB) has been the ancient curse to human and caused by the pathogenic gram positive bacteria Mycobacterium tuberculosis. Nearly 80% of global TB cases occur in developing countries. In 2009, about 55% of ...
Structural, Functional and Stability Studies on Phosphoserine Aminotransferase and D-Phosphoglycerate Dehydrogenase from Entamoeba histolytica

Mishra, Vibhor; Bhakuni, Vinod (Guide) (2011)

To be biologically active, proteins must adopt specific folded three-dimensional tertiary structures. Yet the genetic information for the protein specifies only the primary structure, the linear sequence of amino acids ...

Now showing items 21-40 of 177

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