The intracellular calcium overload is considered a major cause for activating various signaling pathways leading to neuronal death following cerebral ischemia. Earlier this overload was thought mainly due to glutamate ...

Leishmaniases, in its variety of visceral (VL), cutaneous (CL) and mucocutaneous (MCL) forms, directly affects about 2 million people per annum, with approximately 350 million individuals at risk worldwide. During the last ...

Schizophrenia is the most devastating and enduring psychotic disorder affecting as many as 1% of the population worldwide, with a similar prevalence between the both genders, throughout diverse cultures and geographic ...

Indole alkaloids (IAs) are biologically very active secondary metabolites, comprise over 3000 compounds. They have enormous pharmaceutical applications and are isolated from various natural sources including plants. For ...

In mid of 19th century “The Cell Theory” was proposed; which becomes one of the foundations of biology (Karling 1939). According to Henri Dutrochet (1824) “The cell is the fundamental element of organization”. New cells ...

Leishmaniasis (cutaneous, mucocutaneous, and visceral) is caused by an intracellular protozoan parasite complex by the invasion of the reticuloendothelial system (spleen, liver and bone marrow). Leishmaniasis is a zoonotic ...

Tuberculosis (TB) has been the ancient curse to human and caused by the pathogenic gram positive bacteria Mycobacterium tuberculosis. Nearly 80% of global TB cases occur in developing countries. In 2009, about 55% of ...

In recent years, control tools and strategies have become available for lymphatic filariasis. Still there is an unequivocal call for the development of much improved complementary approaches for long-lasting reduction ...