Abstract:
The thesis entitled “Design, Synthesis and Conformational Studies of Peptidomimetics
Containing β-Prolines and Application of Titanium(3) Induced Radical Cyclization of
Epoxyolefins in Natural Product Synthesis” consists of three chapters:
Chapter I: Deals with synthesis of substituted β2,3-proline (β2,3-pro) and β3-homoproline (β3-
Hpro) and conformational study of their homodimers. This chapter consists two parts:
Part A: Describes design and synthesis of substituted β2,3-pro and β3-Hpro.
Part B: Describes synthesis and conformational studies of the homodimers derived from β2,3-pro
and β3-Hpro.
Chapter II: Deals with synthesis and conformational studies of oligomers of β2,3-pro and β3-
Hpro and glycopeptides derived from β3- Hpro.
Chapter III: Deals with application of Titanium(3) induced radical cyclization of epoxyolefins
in natural product synthesis.
