Theses : Recent submissions

Now showing items 1-20 of 177

Synthesis of Oligosaccharides Related to Bacterial Cell Wall Polysacchairdas Steroidal Glycosides and Blood Group Antigens

Karki, Geeta; Mandal, Pintu Kumar (Guide) (PhD Theses submitted by the Research Scholars of CSIR-CDRI, Lucknow, 2019-04-16)

from the Greek word saccharon meaning sugar.3 Carbohydrates that cannot be hydrolyzed into simpler compounds are called “monosaccharides” such as glucose, fructose etc. and a carbohydrate that can be hydrolyzed to two ...
A STUDY ON NEUROINFLAMMATION AND ITS INFLUENCE ON NMDA RECEPTOR AND SYNAPTIC FUNCTION IN STZ (ICV) INDUCED MEMORY IMPAIRED RATS

Rai, Shivika; Shukla, Rakesh (Guide) (PhD Theses submitted by the Research Scholars of CSIR-CDRI, Lucknow, 2015-08-26)

In the present study the role of glial activation and post synaptic toxicity in ICV Streptozotocin (STZ) induced memory impaired rats was explored. In experiment set up 1: Memory deficit was found in Morris water maze test ...
Development and evaluation of Inhalable particdes Containing kanamycin monosulhate and pyrazinoic acid for the treatment of drug resistant tuberculosis.

Srivastava, Ashish; Misra, Amit (Guide) (PhD Theses submitted by the Research Scholars of CSIR-CDRI, Lucknow, 2019-08-22)

Tuberculosis (TB) remains a major health problem and a prime cause of global patient mortality throughout the world. Even after 90 years of vaccination and 60 years of advanced chemotherapy development, we are far away ...
EXPLORING THE FUNCTIONAL SPECTRUM OF HOST DEFENCE PEPTIDES (HDPs)

Raj, Sneha; Pasupuleti, Mukesh (Guide) (PhD Theses submitted by the Research Scholars of CSIR-CDRI, Lucknow, 2019-12-23)

Infectious diseases have been a leading cause of the threat to human existence. Starting from early records of 14th century till mid-20th century, a number of severe outbreaks have taken thousands of human lives in a ...
Isolation, chemical, transformation of natural products and synthesis of natural product analogues of biological importance

Yadav, Pragya; Narender, T (Guide) (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 2020)

The inherent character of natural products as therapeutic agents has been utilised, since the birth of human life on earth. Since ages, the active constituents of most natural sources have been used, which were generally ...
Exploration of self assembled multifunctional nanocarriers for the delivery of anticancer agents

Urandur, Sandeep; Mishra, P. R (Guide) (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 2020)

Cancer is the leading cause of human death worldwide, despite tremendous attempts over several decades to fight cancer with consistent growth in diagnostic and therapeutic approaches. The latest database of GLOBOCAN 2018 ...
Evaluation of the RHOGTPases role in ovarian pathophysiology

Jha, R. K (Guide); Ubba, Vaibhave (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 2020)

Reproduction, both sexual and asexual, is a fundamental and evolving process to sustain life in this universe. Thus, the understanding of this process has been the inspiration to investigators. However, as the mammalian ...
Structural and functional characterization of protein(s) involved in mycobacterial DNA repair

Ramchandran, Ravishankar (Guide); Shukla, Ankita (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 2020)

Mycobacterium tuberculosis is the etiological agent of tuberculosis (TB). The dreaded disease accounts for ~25% of all cases known in the world in India. The pathogen is successful as it is able to evade the host immune ...
Studies on the essentiality of Shikimate Kinase in mycobacteria and characterization of its functional domains with respect to enzyme activity inhibitor binding

Pandey, Sapna; Srivastava, K. K (Guide) (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 2020)
Identification and Characterization of Novel regulator of osteoporosis from endogenous and exogenous sources

Prakash, Ravi; Singh, Divya (Guide) (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 2020)

Osteoporosis is a bone metabolic disorder with compromised bone strength due to low bone mineral density (BMD). It is characterized by low bone mass with impaired bone mineralization, decreased bone strength and worsening ...
Identification of resistance mechanisms and targeting of DNA repair proteins for cancer therapy

Maurya, Pooja; Banerjee, Dibyendu (Guide) (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 2020)

Cancers have the ability to develop resistance to traditional therapies, and the increasing prevalence of these drug-resistant cancers necessitates further research and treatment advancement. Various cellular pathways ...
Computer-aided molecular modeling and structural Bioinformatics Studies for Identification and Design of Anti-tubercular and Anti-leishmanial agents

Kuldeep, Jitendra; Siddiqi, M. I (Guide) (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 2020)

From the very beginning of evolution, the symbiotic interaction between human host with the microorganisms or microbial world is very fascinating. At the time of evolution humans have developed a defence mechanism to ...
Biosynthesis and enrichment of indole alkaloids from Alstonia scholaris through plant tissue culture techniques

Jeet, Amar; Mishra, D. K (Guide) (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 2020)

Indole alkaloids (IAs) are biologically very active secondary metabolites, comprise over 3000 compounds. They have enormous pharmaceutical applications and are isolated from various natural sources including plants. For ...
Design and development of Nano-Sized Formulations of oral delivery of Insulin and C-Peptide

Harsiddharay, R. K; Chourasia, M. K (Guide) (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 2020)

Statistical epidemiology and economic burden of Diabetes Mellitus Diabetes will be the seventh foremost reason of death in 2030 due to an exponential increase in affected peoples from 347 million adults in 2015 to 400 ...
Investigation of Novel Immuno-Metabolic Mechanisms Regulating Inflammasome and Macrophage Activation

Gupta, Priya; Barthwal, M. K (Guide) (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 2020)

Inflammation is the immune system's response to injurious stimuli, such as pathogens, toxic compounds, damaged cells, irradiation, and acts by eliminating harmful stimuli and initiating the healing process. Acute ...
Using reverse genetics to elucidate the role of sporozoite specific proteins S14 and SCOT1 in Plasmodium

Ghosh, Ankit; Mishra, Satish (Guide) (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 2020)

The earliest account found in the literature for malaria was made by Hippocrates in ancient Greece. He made an observation that places around marshes or stagnant water had a higher prevalence of the disease. The Romans ...
Using reverse genetics to elucidate the role of sporozoite specific proteins S14 and SCOT1 in Plasmodium

Ghosh, Ankit; Mishra, Satish (Guide) (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 2020)

The earliest account found in the literature for malaria was made by Hippocrates in ancient Greece. He made an observation that places around marshes or stagnant water had a higher prevalence of the disease. The Romans ...
Structural and Functional Studies of Drp1, a Rint1 Family Protein in Fission Yeast Schizosaccharomyces pombe

Gaurav, Sachin; Ahmed, Shakil (Guide) (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 2020)

Cell is the basic building block of all living organism, broadly divided into prokaryotic cell and eukaryotic cells. Robert Hook a Scottish botanist was known to discover “cell” in 1665 and also recognize the nucleus ...
Development and evaluation of murine models for mycobacterial infection

Das, Swetarka; Dasgupta, Arunava (Guide) (Ph D Theses submitted by the Research Scholars of CDRI, Lucknow, 2020)

This Ph.D. thesis is the result of research work performed under the supervision of Dr. Arunava Dasgupta, in the Microbiology Division of CSIR-Central Drug Research Institute, Lucknow, India during the period of 2015-2019 ...
Delineation of Tyrosine Phosphatase B in Post translational modification of proteins during growth and intracellular survival of Mycobacteria

Dhamija, Ekta; Srivastava, K. K (Guide) (2020)

Tuberculosis (TB), a communicable disease is one of the oldest diseases found to have afflicted its wrath upon mankind since ancient times. Still today it is one of the top 10 causes of fatality around the globe and even ...

Now showing items 1-20 of 177

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