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Now showing items 1141-1160 of 1288

One pot Amberlite IR-120 Catalysed Synthesis of Glycosyl Dihydropyridones

Tiwari, Vinod K; Tewari, Neetu; Katiyar, Diksha; Tripathi, R P (2007)

One pot reaction of β-glycosyl amino acids with β-ketoesters in the presence of IR-120 resin and 4Å molecular sieve in refluxing toluene resulted in respective dihydropyridones in fair to good yields.
Recent Development on Catalytic Reductive Amination and Applications

Tripathi, R P; Verma, Shyam S; Pandey, Jyoti; Tiwari, Vinod K (2008)

Reductive amination is one of the most useful and versatile methods for the preparation of’ amines in biological and chemical systems. The present review focuses on the development of catalytic reductive amination from ...
Synthesis of Galactopyranosyl Amino Alcohols as a new class of Antitubercular and Antifungal Agents

Tewari, Neetu; Tiwari, V K; Tripathi, R P; Chaturvedi, Vinita; Srivastava, A; Srivastava, R; Shukla, P K; Chaturvedi, A K; Gaikwad, A; Sinha, S; Srivastava, B S (2004)

The galactopyranosyl amino alcohols (3-16) were synthesized by regioselective oxirane ring opening of compound 2 with variety of amines and screened for antitubercular and antifungal activities. One of the compounds (16) ...
D-Glucosamine, a natural aminosugar as organocatalyst for an ecofriendly direct aldol reaction of ketones with aromatic aldehydes in water

Singh, Nimisha; Pandey, Jyoti; Tripathi, R P (2008)

D-Glucosamine, one of the important sugars of natural origin catalyzes direct aldol reaction of different aromatic aldehydes with acyclic or cyclic ketones. Diastereo- and enantioselection varies with the substituent on ...
An efficient chemoselective etherification of phenols in polyfunctional aromatic compounds

Pandey, Jyoti; Mishra, Mridul; Bisht, Surendra Singh; Sharma, Anindra; Tripathi, R P (2008)

A simple and efficient chemoselective alkylation of phenols in polyfunctional aromatic compounds with different alkyl halides in the presence of K2CO3/TBAB is reported. The method is successful with various hydroxy aromatic ...
Organocatalysis with Glycosyl Amino acids: Direct Asymmetric Aldol Reaction of Acetone with Aldehydes

Dwivedi, Namrata; Bisht, Surendra Singh; Tripathi, R P (2006)

Direct asymmetric aldol reaction of acetone with aromatic aldehydes using hitherto unprecedented glycosyl acyclic amino acid as a new organocatalyst with high enantioselectivity and good yields is reported.
L-Ascorbic acid in organic synthesis: A facile synthesis of 4-(butenolide-5-methylidenyl)-1, 4-dihydropyridines

Bisht, Surendra Singh; Dwivedi, Namrata; Tripathi, R P (2007)

An efficient synthesis of 4-(butenolide-5-methylidenyl)-1,4-dihydropyridines has been achieved via a three-component reaction of β-keto esters or ketones, ammonium acetate and vinylic aldehydes from ascorbic acid in the ...
NAD+ -dependent DNA ligase: A novel target waiting for the right inhibitor

Dwivedi, Namrata; Dube, Divya; Pandey, Jyoti; Singh, Biswajit; Kukshal, Vandna; Ramachandran, Ravishankar; Tripathi, R P (2008)

DNA ligases (EC.6.5.1.1) are key enzymes that catalyze the formation of phosphodiester bonds at single stranded or double stranded breaks between adjacent 5’phosphoryl and 3’ hydroxyl groups of DNA. These enzymes are ...
Diastereoselective Synthesis and Antifungal Activity of Glycosyl Isoxazolines

Mishra, R C; Tewari, Neetu; Verma, S S; Tripathi, R P; Kumar, Manish; Shukla, P K (2004)

Glycosyl nitrile oxides, generated in situ by reaction of glycosyl oximes (3a, 3b, 4) with N-chlorosuccinimide and DBU, on 1,3-dipolar cycloaddition with substituted alkenes resulted in glycosyl isoxazolines (5, 7-28) in ...
Nad+ dependent dna ligase (rv3014c) from M. tuberculosis: strategies for inhibitor design

Dube, Divya; Kukshal, Vandna; Srivastava, Sandeep Kumar; Tripathi, R P; Ramachandran, Ravishankar (2008)

NAD+ -dependent DNA ligases (LigA) are essential enzymes found only in bacteria and some virus species. This makes them attractive drug targets. Based on the crystal structure of the NAD+ binding domain of the M. tuberculosis ...
Reductive amination of glycoyl aldoses: synthesis of n-glycosylated beta-glycosyl amino alcohols and their antidiabetic potential

Verma, S S; Mishra, R C; Tamrakar, A K; Tripathi, B K; Srivastava, A K; Tripathi, R P (2004)

Reductive amination of glycosyl aldehydes (1a-1c, 2) with glycosyl amino esters (3a-3c, 4) in presence of sodium borohydride gave diglycosylated amino esters (5-15) in good yields. N-Glycosyl-glycosylated amino esters ...
Diastereoselective synthesis of glycosylated prolines as α-glucosidase inhibitors and organocatalyst in asymmetric aldol reaction

Pandey, Jyoti; Dwivedi, Namrata; Srivastava, A K; Tamarkar, A; Tripathi, R P (2007)

1,3-Dipolar cycloaddition of azomethine ylides and glycosyl E-olefins in presence of LDA led to diastereoselective formation of C-glycosylated proline esters. The selected esters on regioselective hydrolysis with LiOH gave ...
DBU assisted Aldol type reaction and elimination: an expeditious synthesis of glycosyl 1,3-dienes via glycosylated beta-hydroxy esters

Verma, Shyam S; Dwivedi, Namrata; Singh, Biswajit K; Tripathi, R P (2006)

A novel method for the synthesis of glycosyl dienes via aldol type condensation has been reported. DBU catalysed condensation of unsaturated glycosyl uronoates with aldehydes produces the corresponding -hydroxy esters, ...
An efficient synthesis of tetramic acid derivatives with extended conjugation from L-Ascorbic Acid

Singh, Biswajit K; Bisht, Surendra Singh; Tripathi, R P (2006)

A straightforward synthesis of tetramic acid derivatives with dienyl susbstituents at C-5 from L-ascorbic acid is reported. The synthesis involves the PCC oxidation of allylic alcohol followed by olefination and subsequent ...
An Efficient Synthesis of Aryloxyphenyl Cyclopropyl Methanone: A New Class of Antimycobacterial Agents

Dwivedi, Namrata; Tewari, Neetu; Tiwari, V K; Chaturvedi, Vinita; Manju, Y K; Srivastava, A; Giakwad, A; Sinha, S; Tripathi, R P (2005)

An efficient, high yield and one pot synthesis of phenyl cyclopropyl methanones on reaction of different aryl alcohols with 4’-fluoro-4-chloro-butyrophenone in THF/DMF in presence of NaH /TBAB is reported. All the compounds ...
Transbilayer phosphatidylethanolamine movements in the yeast plasma membrane evidence for a protein-mediated, energy-dependent mechanism

Balasubramanian, Krishnakumar; Gupta, C M (1996)

Aminophospholipid movements in the plasma membrane of higher eukaryotic cells seem to be regulated by an ATP-dependent, protein-mediated process. To examine whether similar mechanisms exist in yeast cells, we have analysed ...
A Novel Homologue of coronin colocalizes with actin in filament-like structures in Leishmania

Nayak, Ramesh C.; Sahasrabuddhe, Amogh A.; Bajpai, V K; Gupta, C M (2005)

The presence of actin in Leishmania has recently been demonstrated, but the functional form of this protein (filamentous actin) has not yet been identified. We report here that the putative coronin homologue identified in ...
Liposomes mediated drug delivery in infectious diseases

Varshney, G C; Gupta, C M (1996)

Liposome-mediated drug delivery systems along with other newer approaches of drug targeting have revolutionized the measures of controlling parasitic infections, including, malaria, leishmania, fungal infections, besides ...
Asymmetric Distribution of Phosphatidylethanolamine in C. albicans: Possible Mediation by CDRI, a Multidrug Transporter Belonging to ATP Binding Cassette (ABC) Superfamily

Dogra, S; Krishnamurthy, S; Gupta, V; Dixit, B L; Gupta, C M; Sanglard, D; Prasad, R (1999)

By using two molecular probes, we demonstrate that only 4% of total phosphatidylethanolamine (PtdEtn) in the plasma membrane (PM) of a human pathogenic yeast, Candida albicans, is present in its external half. Evidence is ...
Interactions of viral matrix protein and nucleoprotein with the host cell cytoskeletal actin in influenza viral infection

Husain, M; Gupta, C M (1997)

To understand the role of host cell cytoskeleton in regulating the assembly and budding of the externally enveloped viruses, we have studied the interactions between the cytoskeleton and viral proteins in the influenza A ...

Now showing items 1141-1160 of 1288

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