Discovery of amide based fibrates as possible antidyslipidemic and antioxidant agents*

Sashidhara, K V; Palnati, G R; Dodda, R P; Sonkar, Ravi; Khanna, A K; Bhatia, Gitika

dc.contributor.author	Sashidhara, K V
dc.contributor.author	Palnati, G R
dc.contributor.author	Dodda, R P
dc.contributor.author	Sonkar, Ravi
dc.contributor.author	Khanna, A K
dc.contributor.author	Bhatia, Gitika
dc.date.accessioned	2013-02-04T08:43:52Z
dc.date.available	2013-02-04T08:43:52Z
dc.date.issued	2012
dc.identifier.citation	European Journal of Medicinal Chemistry2012, 57, 302–310	en
dc.identifier.uri	http://hdl.handle.net/123456789/988
dc.description.abstract	A novel series of amide based fibrates were synthesized and evaluated for antidyslipidemic activity in triton induced hyperlipidemic rats. Interestingly, the compound 13 produced striking reduction in serum levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG). In addition, it exhibited improved lipoprotein lipase activity and found to possess moderate radical scavenging potential. The results of the above studies shows that the compounds synthesized on fibrate based pharmacophores might result in identification of new lead for dyslipidemia.	en
dc.format.extent	373925 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI communication no. 8324	en
dc.subject	Amide based fibrates	en
dc.subject	Antidyslipidemic	en
dc.subject	Triton model	en
dc.subject	Antioxidant activity	en
dc.title	Discovery of amide based fibrates as possible antidyslipidemic and antioxidant agents*	en
dc.type	Article	en