Abstract:
The intraduodenal route for administering
drugs in experimental animals in acute pharmacodynamic experiments has been tried. Drugs which are absorbed from the duodenum give a prompt response. When crude extracts of the drugs are given, there are fewer side effects due to the solvent. This mode of drug administration, besides giving information on the absorption of the drug, often reveals other pharmacological proper-ties which otherwise remain obscure; intraduodenal administration of Vernonia anthelmintica has revealed a marked inhibition of thoracic respiration in dogs, an observation which has not been reported so far. The technique may be useful
in screening studies on crude extracts of medicinal plants.
