A Quick and Efficient Access to Substituted Quinolines by Electrophilic Cyclization of 1-(2-aminoaryl)-2-yn-1-ols

Reddy, M S; Thirupathi, Nuligonda; Kumar, Y K

dc.contributor.author	Reddy, M S
dc.contributor.author	Thirupathi, Nuligonda
dc.contributor.author	Kumar, Y K
dc.date.accessioned	2012-09-04T10:17:53Z
dc.date.available	2012-09-04T10:17:53Z
dc.date.issued	2012
dc.identifier.citation	RSC Advance, 2012, 2, 3986-3992	en
dc.identifier.uri	http://hdl.handle.net/123456789/893
dc.description.abstract	A practical method for the synthesis of substituted quinolines from 2-aminoarylketones (via 1-(2- aminoaryl)-2-yn-1-ols) using mild and simple reaction conditions is described. A study with several electrophiles in various reaction conditions is presented. Out of three electrophilic iodine sources (I2, NIS and ICl) studied, I2 was found to work efficiently for the synthesis of 3-iodoquinolines. Several Brønsted acids (pTSA, PPTS, AcOH, TFA, HCl) were able to catalyze the formation of 2, 4-substituted quinolines from the same starting materials. Good to excellent overall yields were observed with both aromatic and aliphatic substitutions at the reaction center	en
dc.format.extent	447777 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.subject	Bronsted Acid	en
dc.subject	Electrophilic Cyclization	en
dc.subject	Iodine	en
dc.subject	Quinoline	en
dc.subject	Synthesis	en
dc.title	A Quick and Efficient Access to Substituted Quinolines by Electrophilic Cyclization of 1-(2-aminoaryl)-2-yn-1-ols	en
dc.type	Article	en