Abstract:
Metabolic studies with reserpine in rats have revealed, besides the drug, the presence of 'two metabolites, reserpic acid methyl ester and reserpic acid. These have been detected and identified in tissues, blood, intestinal contents and excreta with the aid of paper partition chromatography. In vitro experiments have established that degradation to reserpic acid methyl ester can occur in the small intestines, while both the metabolites can be formed in the liver.
