Combinatorial synthesis and biological evaluation of isoxazole-based libraries as antithrombotic agents

Batra, Sanjay; Srinivasan, T; Rastogi, S K; Kundu, Bijoy; Patra, A; Bhaduri, A P; Dikshit, Madhu

dc.contributor.author	Batra, Sanjay
dc.contributor.author	Srinivasan, T
dc.contributor.author	Rastogi, S K
dc.contributor.author	Kundu, Bijoy
dc.contributor.author	Patra, A
dc.contributor.author	Bhaduri, A P
dc.contributor.author	Dikshit, Madhu
dc.date.accessioned	2008-01-17T11:16:20Z
dc.date.available	2008-01-17T11:16:20Z
dc.date.issued	2002
dc.identifier.citation	Bioorg. Med. Chem. Lett. 12, 1905-1908, Bioorganic & Medicinal Chemistry Letters 12 (2002) 3349	en
dc.identifier.uri	http://hdl.handle.net/123456789/80
dc.description.abstract	The 3-substitutedphenyl-5-isoxazolecarboxaldehydes have been identified as activated aldehydes for the generation of isoxazole-based combinatorial libraries on solid phase through automation. Three highly functionalized isoxazole-based libraries comprising of 32, 96 and 45 compounds each have been synthesized in parallel format using Baylis Hillman reaction, Michael addition, reductive amination and alkylation reactions. With an objective of lead generation all the three libraries were evaluated for their antithrombin activity in vivo.	en
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dc.format.mimetype	application/pdf
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication no. 6071	en
dc.title	Combinatorial synthesis and biological evaluation of isoxazole-based libraries as antithrombotic agents	en
dc.title.alternative	Corrigendum to ‘‘Combinatorial Synthesis and Biological Evaluation of Isoxazole-Based Libraries as Antithrombotic Agents’’ [Bioorg. Med. Chem. Lett. 12 (2002) 1905]	en
dc.type	Article	en