Medicinal and Process Chemistry: Recent submissions

Now showing items 21-40 of 531

Synthesis and evaluation of new 3-phenylcoumarin derivatives as potential antidepressant agents

Sashidhara, K V; Rao, K B; Singh, Seema; Modukuri, R K; Teja, G A; Chandasana, Hardik; Shukla, Shubha; Bhatta, R S (2014)

A series of amine substituted 3-phenyl coumarin derivatives were designed and synthesized as potential antidepressant agents. In preliminary screening, all compounds were evaluated in forced swimming test (FST), a model ...
Recent Developments in the Side Chain Modified 4-Aminoquinolines As Antimalarial Agents

Dola, V R; Kondaparla, S R; Katti, S B (2014)

The 4-aminoquinolines are considered to be one of the most vital synthetic antimalarial agents. However, control of malaria is threatened by inadequate resources and drug resistance particularly to this class of compounds. ...
Benzofuran-Chalcone Hybrids as Potential Multifunctional Agents against Alzheimer’s disease: Synthesis and in vivo Studies Employing Transgenic Caenorhabditis elegans

Sashidhara, K V; Modukuri, R K; Jadiya, Pooja; Dodda, R P; Kumar, Manoj; Sridhar, Balasubramaniam; Kumar, Vikash; Haque, Rizwanul; Siddiqi, M I; Nazir, Aamir (2014)

In search of effective multifunctional agents for the treatment of Alzheimer’s disease (AD), a series of novel hybrids incorporating benzofuran and chalcone fragments were designed and synthesized. These hybrids were ...
PhI(OAc)2-BF3-OEt2 Mediated Domino Imine Activation, Intramolecular C-C Bond Formation and β-Elimination: New Approach for the synthesis of Fluorenones, Xanthones and Phenanthridines

Sarkar, Satinath; Tadigoppula, Narender (2014)

PhI(OAc)2-BF3-OEt2 mediated domino synthesis of biologically important fluorenones, xanthones and phenanthridines has been developed. The reaction proceeds through imine activation, intramolecular C-C bond formation and ...
Novel Alkylphospholipid-DTC hybrids as promising agents against endocrine related cancers acting via modulation of Akt-pathway

Jangir, Santosh; Bala, Veenu; Lal, Nand; Kumar, Lalit; Sarswat, Amit; Kumar, Amit; Hamidullah; Saini, K S; Sharma, Vikas; Verma, Vikas; Maikhuri, J P; Konwar, Rituraj; Gupta, Gopal; Sharma, V L (2014)

A new series of 2 (alkoxy(hydroxy)phosphoryloxy)ethyl dialkylcarbodithioate derivatives was synthesized and evaluated against endocrine related cancers, acting via modulation of Akt-pathway. Eighteen compounds were active ...
Discovery of 3-arylcoumarin-tetracyclic tacrine hybrids as multifunctional agents against Parkinson’s disease

Sashidhara, K V; Modukuri, R K; Jadiya, Pooja; Rao, K B; Sharma, Tanuj; Haque, Rizwanul; Singh, D K; Banerjee, Dibyendu; Siddiqi, M I; Nazir, Aamir (2014)

A series of multifunctional directed 3-arylcoumarin-tetracyclic tacrine derivatives was designed and synthesized for the treatment of Parkinson’s disease (PD). A number of derivatives (18, 19, 20, 21 and 24) demonstrated ...
Design and Synthesis of Substituted morpholin/piperidin-1-yl-carbamodithioates as promising Vaginal Microbicides with Spermicidal potential

Bala, Veenu; Jangir, Santosh; Kumar, Vikas; Mandalapu, Dhanaraju; Gupta, Sonal; Kumar, Lalit; Kushwaha, Bhavana; Chhonker, Y S; Krishna, Atul; Maikhuri, J P; Shukla, P K; Bhatta, R S; Gupta, Gopal; Sharma, V L (2014)

A series of seventeen morpholin/piperidin-1-yl-carbamodithioate (3-19) were synthesized as topical vaginal microbicidal spermicides. The synthesized compounds were evaluated for their anti-Trichomonas activity against ...
One-pot Synthesis of Highly Fluorescent Pyrido[1,2-a]indole Derivatives via C-H/N-H Activation: Photophysical Investigations and Application in Cell Imaging

Samala, Srinivas; Pallavi, Pragyan; Kumar, Ravi; Arigela, R K; Singh, Gajendra; Ampapathi, R S; Priya, Amulya; Datta, Sunando; Patra, Abhijit; Kundu, Bijoy (2014)

We describe a simple strategy for the synthesis of strongly fluorescent pyridoindoles by Pd catalyzed oxidative annulations of internal alkynes with C-3 functionalized indoles via C-H/N-H bond activation in a one-pot tandem ...
β-Cyclodextrin Catalysed C-C Bond Formation via C(sp3)-H Functionalization of 2-Methyl azaarenes with Diones in aqueous medium

Kumar, Atul; Shukla, R D (2015)

First β-cyclodextrin catalysed C(sp3)-H functionalization of 2-alkyl-azaarenes with homocyclic as well as heterocyclic diones in water has been developed. This bio- mimetic catalyst oriented methodology provides a sustainable ...
Iron nitrate/TEMPO is a superior homogenous catalyst for aerobic oxidation of primary alcohols to nitriles in air

Dighe, S U; Chowdhury, Deepan; Batra, Sanjay (2014)

A highly practical one‐step facile synthesis of aromatic, heteroaromatic, allylic and aliphatic nitriles from primary alcohols catalysed by ferric nitrate (Fe(NO3)3.9H2O) in the presence of TEMPO, aqueous ammonia and air ...
EVALUATION OF ANTIDYSLIPIDEMIC EFFECT OF MANGIFERIN AND AMAROGENTIN FROM SWERTIA CHIRAYITA EXTRACT IN HFD INDUCED CHARLES FOSTER RAT MODEL AND THEIR DOCKING STUDIES

Asthana, R K; Gupta, Rasna; Agrawal, Nidhi; Srivastava, Atul; Chaturvedi, Upma; Kannojiya, Sanjeev; Khanna, A K; Bhatia, Gitika; Sharma, V L (2014)

In continuation of our research programs on bio evaluation of medicinal plants in India, we have investigated antidyslipidemic and antioxidant potential of Swertia chirayita (SC) plant, a potent antidiabetic and its ...
Linearization of carbohydrate derived polycyclic frameworks

Singh, Priyanka; Panda, Gautam (2014)

We report an easy access to carbohydrate derived diverse tricyclic skeletons which could be beneficial for exploring polyfunctionalized chiral alicycles. The key reaction to assemble sugar fused tricyclic core is intermolecular ...
Facile ligand-free Pd-catalyzed tandem C-C/C-N coupling reaction: A novel access to highly diverse tetrazole tag isoindoline derivatives

Sharma, Moni; Khan, Irfan; Khan, Shahnawaz; Mahar, Rohit; Shukla, S K; Kant, Ruchir; Chauhan, P M S (2015)

A novel and robust route for the synthesis of diversely substituted isoindoline skeletons through ligand-free Pd-catalyzed cascade consisting of isocyanide insertion into Ugi-tetrazole has been developed. The tetrazole ...
Substrate-controlled product-selectivity in the reaction of Bestmann-Ohira reagent with N-unprotected isatin-derived olefins

Gupta, A K; Ahamad, Shakir; Gupta, Ekta; Kant, Ruchir; Mohanan, Kishor (2015)

A mild and efficient reaction of Bestmann-Ohira reagent with N-unprotected isatin-derived olefins has been developed for the selective synthesis of spiro-pyrazoline-oxindoles and tricyclic pyrazoles. The reaction features ...
Novel Glycoconjugate of 8-Fluoro Norfloxacin Derivativesas Gentamycin Resistant Staphylococcus aureus Inhibitors: Synthesis and Molecular Modeling Studies

Azad, C S; Bhunia, S S; Krishna, Atul; Shukla, P K; Saxena, A K (2015)

Antibiotic resistance has been the subject of interest in clinical practice due to high prevalence of antibiotic-resistant pathogenic organisms. In view of the prevalence of lesser resistance in antibiotics belonging to ...
Copper-catalyzed highly efficient oxidative amidation of aldehydes with 2-aminopyridines in an aqueous micellar system

Patel, O P S; Anand, Devireddy; Maurya, R K; Yadav, P P (2015)

An environmentally benign and atom economical protocol has been developed for the synthesis of N-(pyridine-2-yl)amides from aldehydes and 2-aminopyridines under mild condition. This approach required Cu(OTf)2 as a catalyst, ...
9-Demethoxy-medicarpin promotes peak bone mass achievement and has bone conserving effect in ovariectomized mice: positively regulates osteoblast functions and suppresses osteoclastogenesis

Goel, Atul; Raghuvanshi, Ashutosh; Kumar, Amit; Gautam, Abnish; Srivastava, Kamini; Kureel, Jyoti; Singh, Divya (2015)

We report a new bone anabolic and anti-catabolic pterocarpan 9-demethoxy-medicarpin (DMM) for the management of postmenopausal osteoporosis. DMM promoted osteoblast functions via activation of P38MAPK/BMP-2 pathway and ...
Functionalized Biaryls as Potent Antihyperglycemic Agents: Synthesis, Molecular Modeling and Biological Evaluation

Goel, Atul; Nag, Pankaj; Rahuja, Neha; Srivastava, Rohit; Chaurasia, Sumit; Gautam, Sudeep; Chandra, Sharat; Siddiqi, M I; Srivastava, A K (2014)

A novel series of functionalized biaryls was designed and synthesized using ketene-S,S-acetal as useful synthon followed by carbanion-induced ring transformation of functionalized lactones. Among various synthesized ...
Molecular Iodine Catalysed One-Pot Synthesis of Chromeno[4,3-b]quinolin-6-ones under Microwave Irradiation

Sashidhara, K V; Palnati, G R; Singh, L R; Upadhyay, Amit; Avula, S R; Kumar, Abdhesh; Kant, Ruchir (2015)

We demonstrate a facile one pot approach for the regioselective synthesis of chromeno[4,3-b] quinoline derivatives in excellent yields under microwave (MW) irradiation. This transformation presumably proceeds via a ...
Reinvestigations into synthesis of allyldithiocarbamates and their intramolecular cyclization: Synthesis and antihyperglycemic activity of 2-thioxothiazolidine-4-alkanoates

Dighe, S U; Yadav, V D; Srivastava, Rohit; Mishra, Akanksha; Gautam, Sudeep; Srivastava, A K; Balaramnavar, V M; Saxena, A K; Batra, Sanjay (2014-09-23)

Reinvestigating the synthesis of allylthiocarbamates from MBH derivatives revealed that they are obtained more efficiently from allylbromides in isopropanol rather than acetates in water. Further unlike reported, the ...

Now showing items 21-40 of 531

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