A New Class Of Potential Chloroquine Resistance Reversal Agents For Plasmodia: Syntheses And Biological Evaluation 1-[(3’-Diethylaminopropyl)-3-(Substituted Phenylmethylene)-Pyrrolidines

Batra, Sanjay; Srivastava, Pratima; Roy, Kamal; Pandey, V C; Bhaduri, A P

dc.contributor.author	Batra, Sanjay
dc.contributor.author	Srivastava, Pratima
dc.contributor.author	Roy, Kamal
dc.contributor.author	Pandey, V C
dc.contributor.author	Bhaduri, A P
dc.date.accessioned	2008-01-17T11:15:03Z
dc.date.available	2008-01-17T11:15:03Z
dc.date.issued	2000
dc.identifier.citation	J. Med. Chem., 43, 3428-3433	en
dc.identifier.uri	http://hdl.handle.net/123456789/79
dc.description.abstract	1-[(3’-Diethylaminopropyl)-3-(substitutedphenylmethylene) pyrrolidines] were synthe-sized and evaluated for CQ resistant reversal activity. The compounds of the series elicit better biological response than their phenyl methyl analogues in general. The most active compound 4b has been evaluated in vivo in details and the results are presented. The possible mode of action of the compounds of this series is by inhibition of the enzyme heme oxygenase, thereby increasing the levels of heme and hemozoin, which are lethal to the parasite.	en
dc.format.extent	135174 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication No. 6024	en
dc.title	A New Class Of Potential Chloroquine Resistance Reversal Agents For Plasmodia: Syntheses And Biological Evaluation 1-[(3’-Diethylaminopropyl)-3-(Substituted Phenylmethylene)-Pyrrolidines	en
dc.type	Article	en