A radical mediated approach to the stereoselective formal total synthesis of (+)-Sch 642305

Chakraborty, Tushar Kanti; Samanta, Rajarshi; Pulukuri, K K

dc.contributor.author	Chakraborty, Tushar Kanti
dc.contributor.author	Samanta, Rajarshi
dc.contributor.author	Pulukuri, K K
dc.date.accessioned	2012-05-24T04:40:29Z
dc.date.available	2012-05-24T04:40:29Z
dc.date.issued	2009
dc.identifier.citation	Tetrahedron 2009, 65(34), 6925–6931	en
dc.identifier.uri	http://hdl.handle.net/123456789/760
dc.description.abstract	Abstract – A formal total synthesis of (+)-Sch-642305 is described. The synthesis, which commenced from a simple chiral synthon (5S)-5-(hydroxymethyl)dihydrofuran-2(3H)-one, employed, as a key step, a radical mediated opening of a chiral epoxy alcohol intermediate with Cp2Ti(III)Cl following an efficient method developed by us earlier. The resultant intermediate radical was intramolecularly trapped by the electron deficient double bond present in the molecule to give rise to its highly functionalized six-membered carbocyclic ring in stereoselective manner.	en
dc.format.extent	251428 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication No. 7780	en
dc.subject	chiral synthon	en
dc.subject	stereoselective	en
dc.subject	dihydrofuran-2(3H)-one	en
dc.title	A radical mediated approach to the stereoselective formal total synthesis of (+)-Sch 642305	en
dc.type	Article	en