Synthesis of oxalamide and triazine derivatives as a novel class of hybrid 4–aminoquinoline with potent antiplasmodial activity

Sunduru, Naresh; Sharma, Moni; Srivastava, Kumkum; Rajakumar, S; Puri, S K; Saxena, J K; Chauhan, P M S

dc.contributor.author	Sunduru, Naresh
dc.contributor.author	Sharma, Moni
dc.contributor.author	Srivastava, Kumkum
dc.contributor.author	Rajakumar, S
dc.contributor.author	Puri, S K
dc.contributor.author	Saxena, J K
dc.contributor.author	Chauhan, P M S
dc.date.accessioned	2012-03-13T04:19:44Z
dc.date.available	2012-03-13T04:19:44Z
dc.date.issued	2009
dc.identifier.citation	Bioorganic & Medicinal Chemistry2009,17, 6451–6462	en
dc.identifier.uri	http://hdl.handle.net/123456789/749
dc.description.abstract	Frequency of malaria and its resistance to chemotherapeutic options are emerging rapidly. To counter this problem, a series of 4–aminoquinolines having oxalamide and triazine functionalities in the side chain were synthesized and screened for their antimalarial activities. Triazine derivative 48 found to be the most active against CQ sensitive strain 3D7 of plasmodium falciparum in an in vitro assay with an IC50 of 5.23 ng/mL and oxalamide derivative 13 showed an in vivo suppression of 70.45% on day 4 against CQ resistant strain N–67 of plasmodium yoelii.	en
dc.format.extent	985990 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication No.7760	en
dc.subject	Antimalarial	en
dc.subject	4–aminoquinoline	en
dc.subject	triazine	en
dc.subject	oxalamide	en
dc.title	Synthesis of oxalamide and triazine derivatives as a novel class of hybrid 4–aminoquinoline with potent antiplasmodial activity	en
dc.type	Article	en