Synthesis and antihyperglycemic activity of phenolic C-glycosides

Rawat, Preeti; Kumar, Manmeet; Rahuja, Neha; Srivastava, D S L; Srivastava, A K; Maurya, Rakesh

dc.contributor.author	Rawat, Preeti
dc.contributor.author	Kumar, Manmeet
dc.contributor.author	Rahuja, Neha
dc.contributor.author	Srivastava, D S L
dc.contributor.author	Srivastava, A K
dc.contributor.author	Maurya, Rakesh
dc.date.accessioned	2011-08-18T11:19:53Z
dc.date.available	2011-08-18T11:19:53Z
dc.date.issued	2011
dc.identifier.citation	Bioorganic & Medicinal Chemistry Letters, 21(1), 228-233	en
dc.identifier.uri	http://hdl.handle.net/123456789/715
dc.description.abstract	Various phenolic C-glycosides were evaluated for their in vitro and in vivo antihyperglycemic activity employing glucose uptake by rat muscle cell lines (L-6) and low dosed-streptozotocin-induced diabetic rats, respectively. Some of phenolic C-glycosides were isolated from Pterocarpus marsupium and Ulmus wallichiana and other were synthesized by unprotected sugar and phloroacetophenone using Sc(OTf)3 in aqueous ethanol. Eight among tested compounds showed significant lowering of blood glucose level on low dosed-streptozotocin-induced diabetic rats. The compound 24 lowered the blood glucose levels by 34.9% and 33.6% during 0–5 h and 0–24 h, respectively, at the dose of 25 mg/kg body weight which is comparable to standard antidiabetic drug metformin	en
dc.format.extent	264694 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	cdricommunicationno.7989	en
dc.subject	Phenolic C-glycosides	en
dc.subject	Antihyperglycemic activity	en
dc.subject	STZ	en
dc.title	Synthesis and antihyperglycemic activity of phenolic C-glycosides	en
dc.type	Article	en