Aza-Annulation on the 16-dehydropregnenolone, via tandem intermolecular Aldol process and intramolecular Michael addition

Kumar, Manmeet; Rawat, Preeti; Khan, M F; Rawat, A K; Srivastava, A K; Maurya, Rakesh

dc.contributor.author	Kumar, Manmeet
dc.contributor.author	Rawat, Preeti
dc.contributor.author	Khan, M F
dc.contributor.author	Rawat, A K
dc.contributor.author	Srivastava, A K
dc.contributor.author	Maurya, Rakesh
dc.date.accessioned	2011-07-15T08:49:16Z
dc.date.available	2011-07-15T08:49:16Z
dc.date.issued	2011
dc.identifier.citation	Bioorganic & Medicinal Chemistry Letters (2011), 21(8), 2232-37	en
dc.identifier.uri	http://hdl.handle.net/123456789/703
dc.description.abstract	16-Dehydropregnenolone undergoes a smooth annulation with propan-1-amine and aromatic aldehydes. Several amine derivatives of 16- dehydropregnenolone were synthesized and evaluated as inhibitors of DPP-IV. The structures of compounds were confirmed by 1H, 13C, NMR and mass spectral analysis. Among seventeen compounds evaluated only five compounds 1, 9, 13, 15 and 16 demonstrated significant inhibition of DPP. This study suggest that introduction of appropriate substituents in the 16-Dehydropregnenolone plays an important role in DPP-IV inhibitory activity.	en
dc.format.extent	184892 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.subject	16-Dehydropregnenolone	en
dc.subject	Annulation	en
dc.subject	DPP-IV	en
dc.subject	Gene	en
dc.subject	Cyclisation	en
dc.title	Aza-Annulation on the 16-dehydropregnenolone, via tandem intermolecular Aldol process and intramolecular Michael addition	en
dc.type	Article	en