Synthesis and Antidyslipidemic Activity of Chalcone Fibrates

Shukla, Poonam; Srivastava, S P; Srivastava, R; Rawat, A K; Srivastava, A K; Pratap, Ram

dc.contributor.author	Shukla, Poonam
dc.contributor.author	Srivastava, S P
dc.contributor.author	Srivastava, R
dc.contributor.author	Rawat, A K
dc.contributor.author	Srivastava, A K
dc.contributor.author	Pratap, Ram
dc.date.accessioned	2011-07-06T10:20:06Z
dc.date.available	2011-07-06T10:20:06Z
dc.date.issued	2011
dc.identifier.citation	Biooganic & Medicinal Chemistry Letters (2011), 21(11), 3475-3478	en
dc.identifier.uri	http://hdl.handle.net/123456789/702
dc.description.abstract	A series of chalcone based PPAR-α agonists were synthesized and evaluated for their antidyslipidemic activity in high fructose high fat fed dyslipidemic Syrian golden hamsters. Most of the compounds exhibited antidyslipidemic activity. The compounds 4c & 4f have been identified as most potent antidyslipidemics. A definite structure-activity relationship was observed while varying the nature as well as the position of the substituent.	en
dc.format.extent	484885 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	cdricommunicationno.8035	en
dc.subject	Chalcones	en
dc.subject	Antidyslipidaemic activity	en
dc.subject	High fructose high fat diet (HFD)	en
dc.subject	Syrian Golden Hamsters	en
dc.title	Synthesis and Antidyslipidemic Activity of Chalcone Fibrates	en
dc.type	Article	en