An efficient regioselective cascade synthesis of N-fused imidazo heterocycles has been developed. This cascade transformation proceeds via a transition-metal (copper/silver) catalyzed coupling reaction between 2-aminoben ...

Introduction: The furiously advancing cases of multidrug-resistant tuberculosis (TB) along with the recent emergence of total drug resistant TB and TB-AIDS comorbidity prompt an increasingly solemn threat to global public ...

Eravacycline (TP-434) is a novel and fully synthetic, broad spectrum IV/oral antibiotic for treatment of complicated urinary tract infections and complicated intra-abdominal infections caused by multi-drug resistant ...

Cerebral malaria (CM) shows lethality rate of 15-25% despite effective antimalarial chemotherapy. The effective adjunct treatment to counteract the CM pathogenesis is urgently required. In murine cerebral malaria model, ...

G protein-coupled receptors (GPCRs) act as a relay center through which extracellular signals, in the form of neurotransmitters or therapeutics, are converted into an intracellular response, which ultimately shapes the ...

Present study was designed to evaluate the antioxidant and hematoprotective activity of methanolic extract of saraca indica bark. Antioxidants and hematoprotective effect of saraca indica bark may be due to its polyphenolic ...

In this investigation, we describe a new approach to chiral synthesis of chloroquine and its analogues. All tested compounds displayed potent activity against chloroquine sensitive as well as chloroquine resistant strains ...

A substituted 5-(piperidine-1-carbonyl)pyrrolidin-2-one (CDRI compound S007-867) is a potent antithrombotic candidate drug under development at our Institute. An HPLC method for determination of S007-867 with its intermediates ...

The 4-aminoquinolines are considered to be one of the most vital synthetic antimalarial agents. However, control of malaria is threatened by inadequate resources and drug resistance particularly to this class of compounds. ...

A library of 3,4,6-triaryl-2-pyridones has been synthesized using multicomponent reaction (MCR) of substituted acetophenones, benzaldehydes and phenyl acetamides. All the synthesized compounds were evaluated for their ...