Recent advances in the design and synthesis of heterocycles as anti-tubercular agents

Abstract

Due to the unusual structure and chemical composition of the mycobacterial cell wall, effective TB treatment is difficult, which makes many antibiotics ineffective and hinders the entry of drugs. With approximately 33% of infection, tuberculosis is still the second most imperative infectious disease worldwide. The most important reason for this is drug resistant TB (MDR, XDR), persistent infection (latent TB) and synergism of TB with HIV; furthermore no any new chemical entity has come in picture in last 40 years. New data available from the recently sequenced genome of the mycobacterium and the application of methods of modern drug design promise to bring significant development in the fight against this disease. In present review we discussed brief introduction of tuberculosis followed