Synthesis and in vitro evaluation of novel coumarin–chalcone hybrids as potential anticancer agents

Sashidhara, K V; Kumar, Abdhesh; Kumar, Manoj; Sarkar, Jayanta; Sinha, S

dc.contributor.author	Sashidhara, K V
dc.contributor.author	Kumar, Abdhesh
dc.contributor.author	Kumar, Manoj
dc.contributor.author	Sarkar, Jayanta
dc.contributor.author	Sinha, S
dc.date.accessioned	2011-05-13T08:38:55Z
dc.date.available	2011-05-13T08:38:55Z
dc.date.issued	2010
dc.identifier.citation	Bioorganic & Medicinal Chemistry Letters, 20(24), 7205-7211	en
dc.identifier.uri	http://hdl.handle.net/123456789/663
dc.description.abstract	A series of coumarin-chalcone hybrids have been synthesized and evaluated for their in vitro cytotoxicity against a panel of four human cancer cell lines and normal fibroblasts (NIH3T3). Among 21 compounds screened, three compounds (23, 25 & 26) showed IC50 range in between 3.59 to 17.97 µM. The most promising compound 26 showed around 30 fold more selectivity towards C33A (cervical carcinoma) cells over normal fibroblast NIH3T3 cells with an IC50 value of 3.59 µM.	en
dc.format.extent	207680 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication No 7961	en
dc.subject	Synthesis	en
dc.subject	Coumarin	en
dc.subject	Chalcone	en
dc.subject	in vitro	en
dc.subject	Cytotoxicity	en
dc.title	Synthesis and in vitro evaluation of novel coumarin–chalcone hybrids as potential anticancer agents	en
dc.type	Article	en