Design and synthesis of novel tetrahydronaphthyl azoles and related cyclohexyl azoles as antileishmanial agents

Marrapu, V K; Srinivas, Nagarapu; Mittal, Monika; Shakya, Nishi; Gupta, Suman; Bhandari, Kalpana

dc.contributor.author	Marrapu, V K
dc.contributor.author	Srinivas, Nagarapu
dc.contributor.author	Mittal, Monika
dc.contributor.author	Shakya, Nishi
dc.contributor.author	Gupta, Suman
dc.contributor.author	Bhandari, Kalpana
dc.date.accessioned	2011-03-21T11:29:34Z
dc.date.available	2011-03-21T11:29:34Z
dc.date.issued	2011
dc.identifier.citation	Bioorganic & Medicinal Chemistry Letters 21 (2011) 1407-1410	en
dc.identifier.uri	http://hdl.handle.net/123456789/657
dc.description.abstract	: A novel series of trans-2-aryloxy-1,2,3,4,-tetrahydronaphthyl azoles and related cyclohexyl azoles were synthesized and evaluated in vitro against Leishmania donovani. Compound 9 identified as most active analog with IC50 value of 0.64 μg/mL and SI value of 34.78 against amastigotes, and is several folds more potent than the reference drugs sodium stilbogluconate and paromomycin. It also exhibited significant in vivo inhibition of 83.33%, and provided a new structural scaffold for antileishmanials.	en
dc.format.extent	235981 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication No 8015	en
dc.subject	Antileishmanial	en
dc.subject	Azoles	en
dc.subject	Aryloxy tetrahydronaphthalene	en
dc.title	Design and synthesis of novel tetrahydronaphthyl azoles and related cyclohexyl azoles as antileishmanial agents	en
dc.type	Article	en