Efficient Synthesis of Congeners based on a Naturally occurring Skeleton 5−7−6 Efficient Synthesis of Congeners based on a Naturally occurring Skeleton 5−7−6 Tricyclic Pyrrolo[2,1-c][1,4] Benzodiazepin-5-one via pi-cyclization

Abstract

An efficient method for the synthesis of a library based on a naturally occurring 5-7-6 tricyclic benzo[e]pyrrolo[1,2-a][1,4]diazepin-5-one skeleton and its derivatives via 7-endo trig Pictet–Spengler pi-cyclization is described.