4-Anilinoquinoline triazines: A novel class of hybrid antimalarial agents

Kumar, Ashok; Srivastava, Kumkum; Rajakumar, S; Siddiqi, M I; Puri, S K; Sexana, J K; Chauhan, P M S

dc.contributor.author	Kumar, Ashok
dc.contributor.author	Srivastava, Kumkum
dc.contributor.author	Rajakumar, S
dc.contributor.author	Siddiqi, M I
dc.contributor.author	Puri, S K
dc.contributor.author	Sexana, J K
dc.contributor.author	Chauhan, P M S
dc.date.accessioned	2011-03-18T08:22:40Z
dc.date.available	2011-03-18T08:22:40Z
dc.date.issued	2010
dc.identifier.citation	European Journal of Medicinal Chemistry 46(2), 11, 676-690	en
dc.identifier.uri	http://hdl.handle.net/123456789/652
dc.description.abstract	A novel class of hybrid 4-anilinoquinoline triazines have been synthesized and evaluated in vitro for their antimalarial activity against CQ-sensitive 3D7 strain of P. falciparum as well as for their cytotoxicity towards VERO cell line. Five compounds (19, 20, 23, 41 and 45) exhibited the antimalarial potency superior to CQ. Compounds 14 and 16 were found to be orally active at a dose of 100 mg/kg x 4 days against CQ-resistant strain of P. Yoelii. Inhibition of β-hematin formation assay and molecular docking study has been conducted in order to gain insight into the mechanism of action of proposed targets for the 4-anilinoquinoline and triazine moiety of the hybrid compounds	en
dc.format.extent	562046 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication No 7995	en
dc.subject	4-Anilinoquinoline triazine	en
dc.subject	Antimalarial	en
dc.subject	P. Falciparum	en
dc.subject	P. Yoelii	en
dc.title	4-Anilinoquinoline triazines: A novel class of hybrid antimalarial agents	en
dc.type	Article	en