An efficient total synthesis of the anticancer agent (+)-spisulosine (ES-285) from Garner’s aldehyde

Ghosal, Partha; Shaw, A K

dc.contributor.author	Ghosal, Partha
dc.contributor.author	Shaw, A K
dc.date.accessioned	2010-12-11T07:26:58Z
dc.date.available	2010-12-11T07:26:58Z
dc.date.issued	2010
dc.identifier.citation	Tetrahedron Letters ,51(2010) 4140–4142	en
dc.identifier.uri	http://hdl.handle.net/123456789/647
dc.description.abstract	An efficient total synthesis of (+)-spisulosine (ES-285) was completed in nine steps from (S)-Garner’s aldehyde. The vicinal amino alcohol moiety with anti-configuration was achieved by a highly diastereoselective addition of vinyl magnesium bromide to Garner’s aldehyde. The long hydrocarbon chain of the antitumor natural product was installed via olefin cross metathesis of the benzyl protected allylic alcohol with an appropriate olefin counterpart followed by hydrogenation.	en
dc.format.extent	151598 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication No 7941	en
dc.subject	anticancer agent	en
dc.subject	diastereoselective	en
dc.subject	allylic alcohol	en
dc.subject	etrosynthetic strategy	en
dc.subject	metathesis product	en
dc.subject	vinyl magnesium bromide	en
dc.title	An efficient total synthesis of the anticancer agent (+)-spisulosine (ES-285) from Garner’s aldehyde	en
dc.type	Article	en