Synthesis and antihyperlipidemic activity of novel coumarin bisindole derivatives

Sashidhara, K V; Kumar, Abdhesh; Kumar, Manoj; Srivastava, Anuj; Puri, Anju

dc.contributor.author	Sashidhara, K V
dc.contributor.author	Kumar, Abdhesh
dc.contributor.author	Kumar, Manoj
dc.contributor.author	Srivastava, Anuj
dc.contributor.author	Puri, Anju
dc.date.accessioned	2010-12-11T07:25:21Z
dc.date.available	2010-12-11T07:25:21Z
dc.date.issued	2010
dc.identifier.citation	Bioorganic & Medicinal Chemistry Letters 20 (2010) 6504–6507	en
dc.identifier.uri	http://hdl.handle.net/123456789/636
dc.description.abstract	A series of novel coumarin bisindole heterocycles were synthesized following an uncommon method and evaluated for their antihyperlipidemic activity in hyperlipidemic hamster model. Among 12 compounds tested, the compound 5e showed potent antihyperlipidemic activity and was found to decrease the plasma triglyceride levels (TG) by 55%, total cholesterol (TC) by 20%, accompanied by an increase in HDL-C/TC ratio by 42% in hyperlipidemic rats to a greater degree than some of the reference statins.	en
dc.format.extent	248232 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication No 7953	en
dc.subject	Synthesis	en
dc.subject	Coumarin	en
dc.subject	Indole	en
dc.subject	Statins	en
dc.subject	Cholesterol lowering	en
dc.subject	Hypolipidemic Agents	en
dc.title	Synthesis and antihyperlipidemic activity of novel coumarin bisindole derivatives	en
dc.type	Article	en