Synthesis and Biological Evaluation of Indolyl Glyoxylamides as a new class of Antileishmanial agents

Chauhan, S S; Gupta, Leena; Mittal, Monika; Vishwakarma, Preeti; Gupta, Suman; Chauhan, P M S

dc.contributor.author	Chauhan, S S
dc.contributor.author	Gupta, Leena
dc.contributor.author	Mittal, Monika
dc.contributor.author	Vishwakarma, Preeti
dc.contributor.author	Gupta, Suman
dc.contributor.author	Chauhan, P M S
dc.date.accessioned	2010-12-11T07:21:11Z
dc.date.available	2010-12-11T07:21:11Z
dc.date.issued	2010
dc.identifier.citation	Bioorganic & Medicinal Chemistry Letters 20 (2010) 6191–6194	en
dc.identifier.uri	http://hdl.handle.net/123456789/633
dc.description.abstract	A series of indolylglyoxylamide derivatives have been synthesized and evaluated in vitro against amastigote form of L. donovani. Compound 8c has been identified as the most active analog of the series with IC50 value of 5.17 µM and SI value of 31.48, and is several folds more potent than the standard drugs sodium stilbogluconate and pentamidine	en
dc.format.extent	154839 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	CDRI Communication No 7952	en
dc.subject	Antileishmanial	en
dc.subject	Indolylglyoxylamides	en
dc.subject	Tetrahydro-β-carboline	en
dc.title	Synthesis and Biological Evaluation of Indolyl Glyoxylamides as a new class of Antileishmanial agents	en
dc.type	Article	en