Application of the modified Pictet-Spengler cyclization reaction for the preparation of imidazopyrazine ring: Synthesis of new pyrido- and pyrimido-imidazopyrazines

Sharma, Sunil; Kundu, Bijoy

dc.contributor.author	Sharma, Sunil
dc.contributor.author	Kundu, Bijoy
dc.date.accessioned	2010-09-09T08:57:12Z
dc.date.available	2010-09-09T08:57:12Z
dc.date.issued	2009
dc.identifier.citation	J Comb Chem. 2009, 11(4), 720-31	en
dc.identifier.uri	http://hdl.handle.net/123456789/605
dc.description.abstract	An efficient and versatile method for the synthesis of imidazopyrazine ring using the modified Pictet-Spengler strategy has been reported. The two step strategy offers rapid assembly of drug-like core templates pyridine or pyrimidine and imidazole into new annulated polycyclic skeletons: pyrido- and pyrimido-imidazopyrazines. The rate of endo cyclization of aryl/heteroaryl- amine substrates have been compared with traditionally used aliphatic amine substrates and results have been discussed in the light of the pKa values of amines present in each substrate.	en
dc.format.extent	222157 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.subject	Pictet Spengler reaction	en
dc.subject	cyclization	en
dc.subject	privileged structures	en
dc.subject	N-rich polycycles	en
dc.subject	fused-ring systems	en
dc.title	Application of the modified Pictet-Spengler cyclization reaction for the preparation of imidazopyrazine ring: Synthesis of new pyrido- and pyrimido-imidazopyrazines	en
dc.type	Article	en