A Mild and Efficient Bisaldolization of Ketones and its Application towards Spirocyclic 1,3-Dioxanes and Novel 1,3,5-Trioxocanes.

Srinivas, Nagarapu; Marrapu, V K; Bhandari, Kalpana

dc.contributor.author	Srinivas, Nagarapu
dc.contributor.author	Marrapu, V K
dc.contributor.author	Bhandari, Kalpana
dc.date.accessioned	2010-09-09T08:56:17Z
dc.date.available	2010-09-09T08:56:17Z
dc.date.issued	2009
dc.identifier.citation	Synlett, 2009,10,1346-1350	en
dc.identifier.uri	http://hdl.handle.net/123456789/599
dc.description.abstract	Bis-aldolization of aryl alkyl ketones as well as cyclic ketones with paraformaldehyde in the presence of catalytic amount L-proline and low concentration of aqueous sodium hydroxide has been developed in excellent yields. Further, these bis-aldols (1a–8a) are elaborated to corresponding spirocyclic dioxanes (9–16a) and novel spirocyclic trioxocanes (10b–16b) in the presence of p-toluene sulfonic acid. The structure and preferred conformation of these eight membered spirocyclic 1,3,5–trioxocanes is discussed.	en
dc.format.extent	126916 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.subject	Bis-aldolization	en
dc.subject	aqueous media	en
dc.subject	Mannich adduct	en
dc.subject	L-proline, spirocylic dioxane	en
dc.subject	Bis-aldol (1,3-diol)	en
dc.subject	natural products	en
dc.title	A Mild and Efficient Bisaldolization of Ketones and its Application towards Spirocyclic 1,3-Dioxanes and Novel 1,3,5-Trioxocanes.	en
dc.type	Article	en