A convenient synthesis of chiral amino acid derived 3,4-dihydro-2H-benzo[b][1,4]thiazines and antibiotic Levofloxacin

Parai, M K; Panda, Gautam

dc.contributor.author	Parai, M K
dc.contributor.author	Panda, Gautam
dc.date.accessioned	2010-09-09T08:54:19Z
dc.date.available	2010-09-09T08:54:19Z
dc.date.issued	2009
dc.identifier.citation	Tetrahedron Letters, 50 ,2009 ,4703–4705	en
dc.identifier.uri	http://hdl.handle.net/123456789/597
dc.description.abstract	A series of 3,4-dihydro-2H-benzo[b][1,4]thiazine derivatives 8a-g were synthesized via- a copper-catalyzed intramolecular N-aryl amination reaction on substituted 2-(2-bromophenylthio)-ethanamines which were synthesized by the nucleophilic substitution reaction of 2-bromobenzenethiol with Boc-protected amino alcohol derivatives. This strategy provides a short and efficient entry to (S)-3-methyl-1,4-benzoxazine 12, an advanced synthetic intermediate for the synthesis of Levofloxacin.	en
dc.format.extent	45505 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.subject	Benzothiazine	en
dc.subject	3,4-dihydro-2H-benzo[b][1,4]thiazine	en
dc.subject	N-aryl amination reaction	en
dc.subject	2-bromobenzenethiol	en
dc.subject	(S)-3-methyl-1,4-benzoxazine 12	en
dc.subject	Levofloxacin	en
dc.title	A convenient synthesis of chiral amino acid derived 3,4-dihydro-2H-benzo[b][1,4]thiazines and antibiotic Levofloxacin	en
dc.type	Article	en