Design and Synthesis of 2-(2,6-Dibromo-phenyl)-3-heteroaryl-1,3-thiazolidin-4-ones as Anti-HIV agents

Rawal, R K; Tripathi, R K; Katti, S B; Pannecouque, Christophe; Clercq, E D

dc.contributor.author	Rawal, R K
dc.contributor.author	Tripathi, R K
dc.contributor.author	Katti, S B
dc.contributor.author	Pannecouque, Christophe
dc.contributor.author	Clercq, E D
dc.date.accessioned	2010-09-09T08:54:08Z
dc.date.available	2010-09-09T08:54:08Z
dc.date.issued	2009
dc.identifier.citation	Eur. J. Med. Chem., 2009,43(12), 2800-2806	en
dc.identifier.uri	http://hdl.handle.net/123456789/596
dc.description.abstract	A series of 2-(2,6-dibromophenyl)-3-heteroaryl-1,3-thiazolidin-4-ones were designed, synthesized and evaluated as selective HIV-1 RT enzyme inhibitors. The results of the HIV-1 RT kit based assay and MT-4 cell tests showed that eight compounds effectively inhibited human immunodeficiency virus type-1 (HIV-1) replication at 20-320 nM concentrations with minimal cytotoxicity in MT-4 as well as in CEM cells.	en
dc.format.extent	147679 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.subject	4-thiazolidinones	en
dc.subject	Anti-HIV activity	en
dc.subject	HIV-1RT	en
dc.subject	NNRTIs	en
dc.title	Design and Synthesis of 2-(2,6-Dibromo-phenyl)-3-heteroaryl-1,3-thiazolidin-4-ones as Anti-HIV agents	en
dc.type	Article	en