An approach towards the total synthesis of (+)-epiquinamide and (+)-α-conhydrine from Garner aldehyde

Srivastava, A K; Das, S K; Panda, Gautam

dc.contributor.author	Srivastava, A K
dc.contributor.author	Das, S K
dc.contributor.author	Panda, Gautam
dc.date.accessioned	2010-09-09T08:52:00Z
dc.date.available	2010-09-09T08:52:00Z
dc.date.issued	2009
dc.identifier.citation	Tetrahedron, 65, 2009, 5322–5327	en
dc.identifier.uri	http://hdl.handle.net/123456789/586
dc.description.abstract	A short and stereoselective route for the synthesis of 1-hydroxyquinolizidine, an advanced synthetic intermediate for the total synthesis of (+)-epiquinamide is presented. The key synthetic steps involve diastereoselective nucleophilic addition on L-serine derived Garner aldehyde and acid mediated (PTSA) ring closing metathesis. The methodology is also elaborated successfully for the total synthesis of (+)-α-conhydrine an important piperidine alkaloid.	en
dc.format.extent	262839 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.subject	quinolizidine	en
dc.subject	indolizidine	en
dc.subject	piperidine	en
dc.subject	1-hydroxyquinolizidine	en
dc.subject	Conium maculatum	en
dc.subject	epipedobates tricolor	en
dc.title	An approach towards the total synthesis of (+)-epiquinamide and (+)-α-conhydrine from Garner aldehyde	en
dc.type	Article	en